2997-92-4

Basic information

• Product Name: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride
• Synonyms: 2,2’-azobis(2-methyl-propanimidamiddihydrochloride;2,2’-azobis(2-methyl-propionamidindihydrochloride;2,2’-azobis[2-methyl-propanimidamiddihydrochloride;ms1;ms1(catalyst);Propanimidamide,2,2’-azobis[2-methyl-,dihydrochloride;v50;2,2'-AZOBIS-2-METHYL-PROPANIMIDAMIDE, DIHYDROCHLORIDE
• CAS NO: 2997-92-4
• Molecular Formula: C₈H₁₈N₆*2ClH
• Molecular Weight: 271.19
• EINECS: 221-070-0
• Product Categories: pharmacetical
• Mol File: 2997-92-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 175-177 °C(lit.)
• Boiling Point: 336.4 °C at 760 mmHg
• Flash Point: 157.3 °C
• Appearance: White to off-white/granular
• Density: 0.42
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: 0-6°C
• Solubility: acetone, dioxane, methanol, ethanol, DMSO and water: soluble
• Water Solubility: 176.2g/L at 20℃
• Stability: Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids.
• CAS DataBase Reference: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride(2997-92-4)
• EPA Substance Registry System: 2,2'-Azobis(2-methylpropionamidine) dihydrochloride(2997-92-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43-5
• Safety Statements: 24-37
• RIDADR: UN 3226 4.1
• WGK Germany: 1
• RTECS: UE4575500
• F: 10-21
• HazardClass: 5.1
• PackingGroup: III
• Hazardous Substances Data: 2997-92-4(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

Uses

Different sources of media describe the Uses of 2997-92-4 differently. You can refer to the following data:
1. 2,2'-Azobis(2-methylpropionamidine) dihydrochloride can be used as free radical initiator, apoptosis inducer.
2. 2,2'-Azobis(2-methylpropionamidine) dihydrochloride is used to prepare Resveratrol and its analogues for use as antioxidants. Also acts as an antioxidant.
3. Free radical initiator.Polymerization initiator for acrylic, vinyl and allyl monomers.

Flammability and Explosibility

Nonflammable

Safety Profile

Poison by ingestion. A skinirritant. When heated to decomposition it emits toxicvapors of NOx and HCl.

Synthetic route

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) + N-(2-methyl-2-propyl)-N-(1-diethylphosphono-2,2-dimethylpropyl)aminoxyl (188526-94-5) → 2-methyl-2-[N-tert-butyl-N-(1-diethoxyphosphoryl-2,2-dimethylpropyl)aminoxy]propinamidine hydrochloride (1034132-99-4)

Conditions	Yield
In ethanol; water at 10℃; for 4.5h; UV-irradiation;	60%

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) → C8H19N6*2ClH

Conditions	Yield
With hydroquinone In methanol at 20℃; Irradiation;

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) → methylpropionamidine radical

Conditions	Yield
With potassium phosphate; potassium chloride In acetonitrile at 22℃; Rate constant;

NAP (59-53-0) + α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) → C8H18N5O + C11H21N4O4S

Conditions	Yield
With nitrogen(II) oxide In water; dimethyl sulfoxide Photolysis;

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) + S-nitroso-N-acetyl-DL-penicillamine (67776-06-1) → C11H20N5O5S

Conditions	Yield
In water; dimethyl sulfoxide at 20℃; Photolysis;

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) + S-nitrosoglutathione → C14H25N6O7S

Conditions	Yield
In water at 64.85℃;

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) → C8H18N5O

Conditions	Yield
With S-nitroso-glutathione In water at 20℃; Photolysis;
With S-nitroso-N-acetylpenicillamine In water at 59.85 - 64.85℃;
With GLUTATHIONE; nitrogen(II) oxide In water at 20℃; Photolysis;

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) + 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt → 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cation radical (790674-36-1)

Conditions	Yield
With Britton-Robinson buffer In ethanol; water at 45℃; for 1h; pH=7.4;

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) → C4H9N2O2*ClH

Conditions	Yield
With Britton-Robinson buffer; oxygen In water; N,N-dimethyl-formamide at 37℃; pH=7.4;

styrene (100-42-5) + sodium hypophosphite (10039-56-2) + aluminium sulfate + α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) → styrene hypophosphite adduct, aluminium salt

Conditions	Yield
Stage #1: styrene; sodium hypophosphite; α,α'-azodiizobutyramidine-dihydrochloride With acetic acid In water at 95℃; for 5h; Stage #2: aluminium sulfate In water

α,α'-azodiizobutyramidine-dihydrochloride (2997-92-4) + potassium ferrocyanide → nitrogen (7727-37-9) + potassium hexacyanoferrate(III)

Conditions	Yield
In aq. phosphate buffer at 37℃; pH=7.4; Kinetics; Electrochemical reaction;