30062-49-8

Basic information

• Product Name: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE
• Synonyms: 5-Propylsulfanyl-[1,3,4]thiadiazol-2-ylamine;2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE;1,3,4-thiadiazol-2-amine, 5-(propylthio)-;[5-(propylthio)-1,3,4-thiadiazol-2-yl]amine;1,3,4-Thiadiazole, 2-amino-5-(propylthio)-
• CAS NO: 30062-49-8
• Molecular Formula: C₅H₉N₃S₂
• Molecular Weight: 175.28
• Mol File: 30062-49-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 117-119 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 330.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 2.70±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE(30062-49-8)
• EPA Substance Registry System: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE(30062-49-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 30062-49-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5-N-propylthio-1,3,4-thiadiazole is a chemical compound with the molecular formula C5H10N4S2. It is a heterocyclic organic compound belonging to the thiadiazole class. 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE contains an amino group and a propylthio group attached to the thiadiazole ring. It has potential applications in the pharmaceutical and agricultural industries, as it may possess various biological activities such as antimicrobial, antiviral, and antifungal properties. However, further research is needed to fully understand its potential uses and effects.

Upstream product

• 106-94-5 propyl bromide 
• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 
• 540-54-5 1-Chloropropane 
• 107-08-4 1-iodo-propane 
• 107-03-9 1-thiopropane 

Downstream Products

• 1309650-78-9 4-(4-chlorobenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-(5-(propylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 
• 1309650-79-0 5-(4-chlorophenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-(5-(propylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 
• 1309650-77-8 4-(4-chlorobenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-(5-(propylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 
• 1408325-11-0 C₂₇H₃₇N₃OS₃ 

Relevant articles and documents

Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection

Zika virus (ZIKV) has become a public health concern worldwide due to its association with congenital abnormalities and neurological diseases. To date, no effective vaccines or antiviral drugs have been approved for the treatment of ZIKV infection, and ne

Synthesis and Bioactivity Evaluation of Novel Thiochroman-4-One Derivatives Incorporating Carboxamide and 1, 3, 4-Thiadiazole Thioether Moieties

A series of novel thiochroman-4-one derivatives incorporating carboxamide and 1, 3, 4-thiadiazole thioether moieties were synthesized. Bioassay results indicated that the EC50 values of compound 6-chloro-N-(5-(methylthio)-1, 3, 4-thiadiazol-2-yl)-4-oxothiochromane-2-carboxamide (5a) against Xanthomonas oryzae pv. Oryzae (Xoo) and Xanthomonas axonopodis pv. Citri (Xac) were 24 and 30 μg/mL, respectively, which were even better than those of bismerthiazol and thiadiazole copper. Meanwhile, compound 6-methyl-4-oxo-N-(5-(propylthio)-1, 3, 4-thiadiazol-2-yl)thiochromane-2-carboxamide (5m) showed a better antifungal activity against Botrytis cinerea (B. cinerea), with an inhibition rate of 69%, than carbendazim. As far as we know, this is the first report on the antibacterial and antifungal activities of this series of novel thiochroman-4-one derivatives incorporating carboxamide and 1, 3, 4-thiadiazole thioether moieties.

Design and development of 1,3,4-thiadiazole based potent new nano-fungicides

Being the important organic reaction intermediates and biological scaffolds, a series of 2-alkyl/aralkyl/heterocyclyl sulfanyl-5-amino/methyl-1,3,4-thiadiazoles have been synthesized by suitable synthetic route and characterized by analytical and spectral data. The evaluation of these compounds for their bioefficacy against two phyto-pathogenic fungi revealed their fungicidal potency against Rhizoctonia bataticola (ED50 values, 3.9–300.4 μg/mL) and Rhizoctonia solani (ED50 values, 4.2–228.5 μg/mL). To further augment their fungicidal efficacy, the potent five fungicidal compounds were nano-sized. The protocol for preparing 1,3,4-thiadiazole based nano-fungicide employing polyethylene glycol was developed and standardized. Characterization of nano-forms of 1,3,4-thiadiazole derivatives by particle size analyzer and electron microscopy (TEM) techniques confirmed the 100 nm average particle sizes of all nano-fungicides. The 2–4 times higher fungicidal activity was observed with nano-forms than the corresponding conventional sized 1,3,4-thiadiazole derivatives against phytopathogenic fungi, namely, Rhizoctonia solani and R. bataticola.