30309-80-9

Basic information

• Product Name: Phosphine oxide, bis(2-methylphenyl)-
• CAS NO: 30309-80-9
• Molecular Formula: C14H15OP
• Molecular Weight: 230.246
• Mol File: 30309-80-9.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: Phosphine oxide, bis(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphine oxide, bis(2-methylphenyl)-(30309-80-9)
• EPA Substance Registry System: Phosphine oxide, bis(2-methylphenyl)-(30309-80-9)

Safety Data

• Hazardous Substances Data: 30309-80-9(Hazardous Substances Data)

Upstream product

• 6921-34-2 benzylmagnesium chloride 
• 95-46-5 2-methylphenyl bromide 
• 352-70-5 m-Fluorotoluene 
• 762-04-9 phosphonic acid diethyl ester 
• 6163-63-9 tri-o-tolylphosphine oxide 
• 36042-94-1 bis(o-tolyl)chlorophosphine 
• 95-49-8 2-methylchlorobenzene 
• 762-04-9 Diethyl phosphonate 
• 932-31-0 ortho-tolylmagnesium bromide 

Downstream Products

• 69520-29-2 2-hexyl-1-decen-3-yne 
• 13343-79-8 (E)-1,4-Diphenylbut-1-en-3-yne 
• 1315513-14-4 C₂₀H₂₇O₂P 
• 149222-24-2 tetra(o-tolyl)diphosphane 

Relevant articles and documents

Enantiodivergent Kinetic Resolution of 1,1′-Biaryl-2,2′-Diols and Amino Alcohols by Dipeptide-Phosphonium Salt Catalysis Inspired by the Atherton–Todd Reaction

A highly enantiodivergent organocatalytic method is disclosed for the synthesis of atropisomeric biaryls via kinetic resolution inspired by a dipeptide-phosphonium salt-catalyzed Atherton–Todd (A-T) reaction. This flexible approach led to both R- and S-enantiomers by fine-tuning of bifunctional phosphonium with excellent selectivity factors (s) of up to 1057 and 525, respectively. The potential of newly synthesized O-phosphorylated biaryl diols was illustrated by the synthesis of axially chiral organophosphorus compounds. Mechanistic investigations suggest that the bifunctional phosphonium halide catalyst differentiates between the in-situ-generated P-species in the A-T process, mainly involving phosphoryl chloride and phosphoric anhydride, thus leading to highly enantiodivergent O-phosphorylation reactions. Furthermore hydrogen bonding interactions between the catalysts and phosphorus molecules were crucial in asymmetric induction.

Synthesis of benzyl sulfidesviasubstitution reaction at the sulfur of phosphinic acid thioesters

An ambident electrophilicity of phosphinic acid thioesters is disclosed. Unexpected carbon-sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. The developed method for benzyl sulfides has a wide substrate scope and was applicable for the synthesis of a drug analog.

Copper mediated C(sp2)-H amination and hydroxylation of phosphinamides

Copper mediated C(sp2)-H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group. This method is distinguished by its wide substrate scope and excellent functional group tolerance, th