30566-92-8

Basic information

• Product Name: 5-(N,N-Dibenzylglycyl)salicylamide
• Synonyms: 5-(N,N-DIBENZYLGLYCYL)SALICYLAMIDE;5-(N,N-Dibenzylglcyl)salicylamide;5-(N,N-Dibenzylacetyl)Salicylamide;5-N,N-Dibenzylglycyl;5-(N,N-DIBENZYLGLYCYL)SALICYLAMIDE 98%;5-[[Bis(benzyl)amino]acetyl]salicylamide;5-[[Bis(phenylmethyl)amino]acetyl]-2-hydroxybenzamide;5-(N,N-Dibenzylglycyl)salicylamide,98%
• CAS NO: 30566-92-8
• Molecular Formula: C₂₃H₂₂N₂O₃
• Molecular Weight: 374.43
• EINECS: 250-244-9
• Mol File: 30566-92-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 168 °C
• Boiling Point: 503.44°C (rough estimate)
• Flash Point: 298.7 °C
• Appearance: light beige powder
• Density: 1.2085 (rough estimate)
• Vapor Pressure: 1.31E-13mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• PKA: 6.27±0.20(Predicted)
• CAS DataBase Reference: 5-(N,N-Dibenzylglycyl)salicylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(N,N-Dibenzylglycyl)salicylamide(30566-92-8)
• EPA Substance Registry System: 5-(N,N-Dibenzylglycyl)salicylamide(30566-92-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 30566-92-8(Hazardous Substances Data)

Usage

Chemical Properties

light beige powder

Uses

5-(N,N-Dibenzylglycyl)-salicylamide is used in preparation of 5-(N,N-Dibenzyl Amino)acetylsalicylamide as intermediate for labetalol drug synthesis.

InChI:InChI=1/C23H22N2O3/c24-23(28)20-13-19(11-12-21(20)26)22(27)16-25(14-17-7-3-1-4-8-17)15-18-9-5-2-6-10-18/h1-13,26H,14-16H2,(H2,24,28)/p+1

Upstream product

• 6629-80-7 2-Phenyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 65-45-2 salicylamide 
• 30914-88-6 2,2-dimethyl-4-keto-1,3-benzoxazine 
• 103-49-1 dibenzylamine 
• 33254-88-5 5-chloroacetylsalicylamide 
• 73866-23-6 5-(2-bromoacetyl)-2-hydroxybenzamide 

Downstream Products

• 54645-51-1 2-Butyloxy-5-(N,N-dibenzylglycyl)benzamide 
• 81579-56-8 5-{2-[2-(3,4-Dihydro-2H-quinolin-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide 
• 81580-13-4 5-{2-[3-(4-Dimethylamino-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide 
• 72371-11-0 5-(2-[3-(N-methylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide 
• 81580-04-3 5-{2-[2-(Ethyl-phenyl-amino)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide 
• 81580-24-7 2-Hydroxy-5-(1-hydroxy-2-{2-[(4-methoxy-phenyl)-methyl-amino]-1-methyl-ethylamino}-ethyl)-benzamide 
• 81580-11-2 4-{3-[2-(3-Carbamoyl-4-hydroxy-phenyl)-2-hydroxy-ethylamino]-butyl}-benzoic acid methyl ester 
• 81580-21-4 5-(2-[3-(N,4-dimethylanilino)-2-propylamino]-1-hydroxyethyl)-salicylamide 
• 81580-22-5 5-(2-{2-[(4-Fluoro-phenyl)-methyl-amino]-1-methyl-ethylamino}-1-hydroxy-ethyl)-2-hydroxy-benzamide 
• 81579-55-7 5-{2-[2-(2,3-Dihydro-indol-1-yl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide 
• 81580-20-3 5-{2-[2-(Benzo[1,3]dioxol-5-yloxy)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide 
• 81580-12-3 5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride 
• 30566-93-9 5-(N,N-dibenzylglycyl)-o-anisamide 
• 32780-64-6 labetalol hydrochloride 

Relevant articles and documents

Synthetic method of 5-N,N-dibenzylamine acetyl salicylamide

The invention discloses a synthetic method of 5-N,N-dibenzylamine acetyl salicylamide. The synthetic method comprises the steps of protecting salicylamide with aldehyde, ketone or acetal and ketal with different substituents, reacting with an alpha-halogenated acylation reagent so as to obtain an intermediate II, substituting halogen atoms with dibenzylamine, and finally carrying out acidificationdeprotection, so as to obtain 5-N,N-dibenzylamine acetyl salicylamide. The synthetic method provided by the invention has the characteristics of high yield, few impurities, low cost, easiness in amplification and the like.

Arylethanolamines derived from salicylamide with α- and β-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers, and related salicylamides

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