306-44-5 Usage
Uses
(E)-2-oxopropanal oxime can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and pharmaceutical and chemical production processes.
Preparation
To a well-stirred, ice-cooled solution of 5.8 gm (0.1 mole) of acetone in 30 ml of glacial acetic acid is added dropwise a concentrated aqueous solution containing 15 gm of sodium nitrite. Stirring at 0°C is continued for 45 min, then 100 ml of water is added and the crude product is extracted with ether.
The ether extracts are combined, washed repeatedly with 10 ml portions of water, and dried with sodium sulfate. The ether is evaporated off under reduced pressure and the residue is dried on a porous plate. After recrys-tallization from benzene, 6 gm (69%) of the product is isolated, m.p. 65°C.
Synthesis
under the condition of the ice, to 1000 ml three port successively added in the bottle KOH (58.35g, 1 . 16eq, 1 . 04mol) and 585 ml water, the reaction system is cooled to 0 °C, adding to the reaction system (103.61g, 1eq, 0.892mol), after stirring at room temperature add 24h; once again the reaction system is cooled to 0 °C, in the reaction system by adding NaNO2(71.76g, 1 . 16eq, 1 . 04mol), the reaction system to maintain 0 °C, to wherein the dropwise H2SO4(50%), the for PH 4-5 (adding sulphuric acid to the volume to the final system is PH), stir at room temperature 2h, this will produce a large amount of gas in the process, a white precipitate, then in to the system by adding NaOH (35%) solution, the for PH 9-10, finally in the reaction system by adding 100 ml of toluene, the organic phase and aqueous phase separation, is added to the aqueous phase H2SO4(50%) the adjusted to PH 5-6, ethyl acetate (3*100 ml) extraction, anhydrous sodium sulfate for drying, can be obtained turns on lathe does white solid 61 . 3g (yield 79%).
Check Digit Verification of cas no
The CAS Registry Mumber 306-44-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 306-44:
(5*3)+(4*0)+(3*6)+(2*4)+(1*4)=45
45 % 10 = 5
So 306-44-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO2/c1-3(5)2-4-6/h2,6H,1H3/b4-2+
306-44-5Relevant articles and documents
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Singer,Vamplew
, p. 3052 (1957)
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Involvement of the Enol Tautomers in the Nitrosation of Ketones
Leis, J. Ramon,Pena, M. Elena,Williams, D. Lyn H.
, p. 45 - 47 (1987)
Nitrosation of ketones involves reaction of the enol form; the rate limiting step can be either formation of the enol, or its reaction with the nitrosating agent.
Sterilization compound and preparation method and application thereof
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Paragraph 0021; 0047; 0048; 0049, (2016/10/27)
The invention relates to the field of agricultural plant protection, and particularly relates to a sterilization compound and a preparation method and an application thereof. The compound has the structure represented by a formula defined in the specification, wherein R is selected from one of components defined in the specification; the compound has excellent bacteriostatic activity on potato phytophthora infestans, phytophthora capsici, phytophthora nicotianae, peronophthora litchii, pseudoperonospora cubensis and other plant pathogenic oomycetes, and has broad application prospects in prevention and control of oomycete diseases.
Palladium-Catalyzed Direct Arylation of Azine and Azole N-Oxides: Reaction Development, Scope and Applications in Synthesis
Campeau, Louis-Charles,Stuart, David R.,Leclerc, Jean-Philippe,Bertrand-Laperle, Megan,Villemure, Elisia,et al.
supporting information; experimental part, p. 3291 - 3306 (2009/07/30)
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