31560-20-0

Basic information

• Product Name: METHYL N-BENZOYL-4-HYDROXYPROLINATE
• Synonyms: METHYL N-BENZOYL-4-HYDROXYPROLINATE;Bzl-Hyp-Ome;Methyl (4R)-1-benzoyl-4-hydroxy-L-prolinate
• CAS NO: 31560-20-0
• Molecular Formula: C₁₃H₁₅NO₄
• Molecular Weight: 249.26
• Mol File: 31560-20-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 414.3oC at 760 mmHg
• Flash Point: 204.4oC
• Appearance: /
• Density: 1.302g/cm3
• Vapor Pressure: 1.31E-07mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL N-BENZOYL-4-HYDROXYPROLINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL N-BENZOYL-4-HYDROXYPROLINATE(31560-20-0)
• EPA Substance Registry System: METHYL N-BENZOYL-4-HYDROXYPROLINATE(31560-20-0)

Safety Data

• Hazardous Substances Data: 31560-20-0(Hazardous Substances Data)

Usage

General Description

Methyl N-benzoyl-4-hydroxyprolinate is a chemical compound that falls under the class of Pyrrolidine and pyrrolidine derivatives. These are compounds containing a pyrrolidine ring, which is a five-membered saturated ring with one nitrogen atom and four carbon atoms. Lacking large scale industrial applications, this chemical compound is mainly utilized in scientific research and development. Currently, no significant information is available about its toxicity or potential dangers, implying that investigations on its effect on health and the environment are limited or not yet conducted.

InChI:InChI=1/C13H15NO4/c1-18-13(17)11-7-10(15)8-14(11)12(16)9-5-3-2-4-6-9/h2-6,10-11,15H,7-8H2,1H3/t10-,11+/m1/s1

Upstream product

• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 98-88-4 benzoyl chloride 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 66831-17-2 (2S,4R)-methyl 4-(benzyloxy)pyrrolidine-2-carboxylate hydrochloride 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 340740-03-6 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzoyl-prolin-methyl-ester 
• 1094039-81-2 (2S)-methyl N-benzoyl-4-methylenepyrrolidine-2-carboxylate 
• 1356446-78-0 fosinopril 
• 103201-78-1 (2S,4S)-4-cyclohexylpyrrolidine-2-carboxylic acid 
• 96314-26-0 trans-4-phenyl-L-proline 
• 960008-99-5 methyl (2S,4S)-1-(tert-butoxycarbonyl)-4-[3-(methoxycarbonyl)-5-(methylcarbamoyl)-phenoxy]pyrrolidine-2-carboxylate 
• 960008-96-2 methyl (2S,4S)-1-benzoyl-4-[2-bromo-4-(methoxycarbonyl)phenoxy]pyrrolidine-2-carboxylate 
• 960008-92-8 methyl (2S,4S)-1-benzoyl-4-[4-(methoxycarbonyl)phenoxy]pyrrolidine-2-carboxylate 
• 960008-94-0 methyl (2S,4S)-1-benzoyl-4-(2-methoxycarbonyl-4-methylphenoxy)pyrrolidine-2-carboxylate 
• 120851-71-0 (2S,4S)-1-Benzoyl-4-phenyl-pyrrolidine-2-carboxylic acid 
• 120807-16-1 (2S,4R)-1-Benzoyl-4-chloro-pyrrolidine-2-carboxylic acid 
• 171897-35-1 methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate 
• 171897-42-0 methyl (2R,4R)-1-benzoyl-4-(4-chlorophenyl)-4-hydroxy-2-pyrrolidinecarboxylate 
• 171897-37-3 methyl (2S,4R)-1-benzoyl-4-(4-chlorophenyl)-2-pyrrolidinecarboxylate 

Relevant articles and documents

PYRROLO PYRIMIDINONE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel compound that has inhibitory action on prolyl hydroxylases (PHDs) and is useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis. SOLUTION: This invention relates to a pyrrolo pyrimidinone compound represented by the formula (I) or a pharmacologically acceptable salt thereof. The compound or a pharmacologically acceptable salt thereof has inhibitory action on prolyl hydroxylases and is useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Cyclopropenone catalyzed substitution of alcohols with mesylate ion

The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.

Asymmetric synthesis of α-branched primary amines on solid support via novel hydrazine resins

Matrix presented Two novel chiral hydrazine resins for asymmetric solid-phase synthesis have been developed. The enantiopure β-methoxyamino auxiliaries, derived from frans-4-hydroxy-(S) -proline and (R) -leucine, were attached to Merrifield resin and transformed into their corresponding hydrazines. Immobilization of various aldehydes, followed by 1,2-addition of organolithium reagents to the resulting enantiopure hydrazones and reductive cleavage from the solid support, furnished α-branched amines, which were isolated as their corresponding amides in good overall yields and enantiomeric excesses of up to 86%.