31588-18-8 Usage
General Description
3-HYDROXY-2-PHENYL-2,3-DIHYDRO-4(1H)-QUINOLINONE, also known as norcantharidin, is a synthetic quinoline derivative with potential anticancer and antitumor activities. It selectively inhibits protein phosphatase 2A (PP2A), leading to cell cycle arrest and apoptosis in cancer cells. 3-HYDROXY-2-PHENYL-2,3-DIHYDRO-4(1H)-QUINOLINONE has shown promising results in preclinical studies, demonstrating its ability to inhibit tumor growth and metastasis in various cancer types, including lung, breast, and prostate cancer. Additionally, it has also been found to suppress angiogenesis and enhance the immune response against cancer cells. Due to its potential therapeutic benefits, 3-HYDROXY-2-PHENYL-2,3-DIHYDRO-4(1H)-QUINOLINONE is currently being investigated as a novel anticancer agent.
Check Digit Verification of cas no
The CAS Registry Mumber 31588-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,5,8 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 31588-18:
(7*3)+(6*1)+(5*5)+(4*8)+(3*8)+(2*1)+(1*8)=118
118 % 10 = 8
So 31588-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H11NO2/c17-14-11-8-4-5-9-12(11)16-13(15(14)18)10-6-2-1-3-7-10/h1-9,18H,(H,16,17)
31588-18-8Relevant articles and documents
Acid catalyzed rearrangements of aryl 3-(2-nitroaryl)oxiran-2-yl ketones
Gubaidullin, A. T.,Khikmatova, G. Z.,Korshin, D. E.,Krivolapov, D. B.,Mahrous, E. M.,Mamedov, V. A.,Mamedova, V. L.,Sinyashin, O. G.
, p. 510 - 516 (2020/04/17)
Studies of chemical behavior of aryl 3-(2-nitrophenyl)oxiran-3-yl ketones in acidic medium revealed the possible occurrence of two competitive rearrangements leading to 2-(2-oxo-2-arylacetamido)benzoic acids and 3-hydroxyquinolin-4(1H)-ones.
Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues
Hodgkinson, James T.,Galloway, Warren R. J. D.,Saraf, Shreya,Baxendale, Ian R.,Ley, Steven V.,Ladlow, Mark,Welch, Martin,Spring, David R.
supporting information; experimental part, p. 57 - 61 (2011/02/23)
Expedient syntheses of Pseudomonas quinolone signal (PQS) and related structural analogues using microwave and flow methods are reported.
Solid-state induced heterocyclization under microwave irradiation: Synthesis of 2-phenyl-3-hydroxy-quinolin-4(1H)-one
Heravi, Majid M.,Oskooie, Hossein A.,Bahrami, Lila,Ghassemzadeh, Mitra
, p. 779 - 781 (2007/10/03)
Synthesis of 2-phenyl-3-hydroxy-quinolin-4(1H)-one under microwave irradiation in solventless system has been described. The mechanism of the reaction is also discussed.
