31753-17-0 Usage
Description
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
Check Digit Verification of cas no
The CAS Registry Mumber 31753-17-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,5 and 3 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31753-17:
(7*3)+(6*1)+(5*7)+(4*5)+(3*3)+(2*1)+(1*7)=100
100 % 10 = 0
So 31753-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H34O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h5,8,13-14,16-18,20,22,24H,3-4,6-7,9-12,15H2,1-2H3/b8-5+,14-13+/t16-,17+,18+,20+/m0/s1
31753-17-0Relevant articles and documents
Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries
Chen, Shaoqing,Janda, Kim D.
, p. 8724 - 8725 (1997)
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Novel and flexible entries into prostaglandins and analogues based on ring closing alkyne metathesis or alkyne cross metathesis
Furstner,Grela,Mathes,Lehmann
, p. 11799 - 11805 (2007/10/03)
The suitably functionalized cyclopentanone derivatives 12, 13, 19, and 37 serve as common precursors for the synthesis of various prostaglandins, prostaglandin-1,15-lactones, and unnatural analogues thereof. All of them contain a 2-butynyl entity which is
Enantioselective Rh-Mediated Synthesis of (-)-PGE2 Methyl Ester
Taber, Douglass F.,Hoerrner, R. Scott
, p. 441 - 447 (2007/10/02)
Intramolecular Rh(II) carboxylate catalyzed cyclization of an α-diazo β-methylene ketone to form a fused cyclopropane is shown to compete efficiently with β-hydride elimination, so long as a catalyst derived from an electron-donating carboxylate is used.C