31827-04-0Relevant articles and documents
Improved scalable synthesis and biological activity of “indoxyl-gal,” a chromogenic histochemical used for the identification of lac+ organisms
Banasik, Brent,Mai, Tam,Samadpour, Mansour
supporting information, p. 822 - 825 (2018/11/06)
An improved and operationally simple synthesis of 3-indoxyl-β-D-galactopyranoside (in-doxyl-gal) is disclosed. Indoxyl-gal is a sensitive chromogenic histochemical used for the identification of β-galactosidase enzymatic activity (lacZ gene). Synthesis of indoxyl-gal is improved to 25% overall yield in 5 linear steps from affordable starting materials with minimal chromatography. Biological testing confirmed the detection of β-galactosidase activity in all (100%, 19 strains) coliform bacteria using membrane filtration and modified MI agar.
3-substituted indole antiproliferative angiogenesis inhibitors
-
, (2008/06/13)
3-Substituted indole carbohydrazides having the formula are useful for inhibiting angiogenesis and cell proliferation. Also disclosed are compositions which inhibit angiogenesis and cell proliferation and methods of inhibiting angiogenesis and cancer in a mammal.