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31868-18-5

31868-18-5

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31868-18-5 Usage

Description

Mexazolam is a benzodiazepine anxiolytic closely related to flutazolam. It is reported to be particularly effective against psychosomatic essential hypertension, peptic ulcer, irritable colon and autonomic dystonia.

Originator

Sankyo (Japan)

Uses

Mexazolam is a benzodiazepine derivative and have been investigated for its therapeutic value in treating anxiety. Mexazolam is known to be metabolized via the CYP3A4 pathway.

Brand name

MELEX

Check Digit Verification of cas no

The CAS Registry Mumber 31868-18-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,8,6 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 31868-18:
(7*3)+(6*1)+(5*8)+(4*6)+(3*8)+(2*1)+(1*8)=125
125 % 10 = 5
So 31868-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23)

31868-18-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

1.2 Other means of identification

Product number -
Other names mexazolam

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31868-18-5 SDS

31868-18-5Synthetic route

2-Amino-1-propanol
6168-72-5

2-Amino-1-propanol

2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone
5504-92-7

2-(2-bromo-acetylamino)-5,2'-dichloro-benzophenone

mexazolam
31868-18-5

mexazolam

Conditions
ConditionsYield
(i) CH2Cl2, (ii) AcOH, EtOH; Multistep reaction;
7-Chloro-5-(2-chloro-phenyl)-4-(2-hydroxy-1-methyl-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium

7-Chloro-5-(2-chloro-phenyl)-4-(2-hydroxy-1-methyl-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium

mexazolam
31868-18-5

mexazolam

Conditions
ConditionsYield
With borate buffer (pH=8-10.5) In ethanol; water Equilibrium constant; Mechanism; variation of pH and buffers.;
In ethanol; water at 25℃; Rate constant;
mexazolam
31868-18-5

mexazolam

methyl iodide
74-88-4

methyl iodide

10-chloro-11b-(2-chloro-phenyl)-3,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
32711-03-8

10-chloro-11b-(2-chloro-phenyl)-3,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one

Conditions
ConditionsYield
(i) NaOMe, MeOH, (ii) /BRN= 969135/, DMF; Multistep reaction;
mexazolam
31868-18-5

mexazolam

7-Chloro-5-(2-chloro-phenyl)-4-(2-hydroxy-1-methyl-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium

7-Chloro-5-(2-chloro-phenyl)-4-(2-hydroxy-1-methyl-ethyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water Equilibrium constant; Mechanism; variation of pH and buffers.;
In ethanol; water at 25℃; Rate constant;

31868-18-5Downstream Products

31868-18-5Relevant articles and documents

Kinetics and mechanism of the acid-base equilibrium of mexazolam and comparison with those of other commercial benzodiazepinooxazole drugs

Kuruno,Kamiya,Kuwayama,Jinno,Yashiro,Ikeda

, p. 3831 - 3837 (2007/10/02)

-

Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo[6,7]-1,4-diazepino[5,4-b]oxazole derivatives and analogs.

Miyadera,Terada,Fukunaga,Kawano,Kamioka,Tamura,Takagi,Tachikawa

, p. 520 - 526 (2007/10/08)

-

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