Detail of "31868-18-5"

CAS Number:
31868-18-5
Name:
Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one,10-chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro-3-methyl-
Molecular Structure:
Formula:
C18H16 Cl2 N2 O2
Molecular Weight:
363.26
Synonyms:
CS 386;Melex; Mexazolam
Density:
1.44 g/cm³
Boiling Point:
522.2 °C at 760 mmHg
Flash Point:
269.6 °C
Safety:
Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. Details

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Behavioral pharmacology of antianxiety drugs: Behavioral pharmacology of antianxiety drugs. Kamioka, Toshiharu; Nakayama, Isao; Karube, Toshio (Biol. Res. Lab., Sankyo Co., Ltd., Japan). Neurosciences (Kobe, Jpn.), 9(2), 176-87 (Japanese) 1984. CODEN: NUOCDO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Oxazolam [24143-17-7] and chlordiazepoxide [58-25-3] given orally to monkeys at 2 mg/kg increased the animals' sex activity, whereas mexazolam [31868-18-5] and diazepam [439-14-5] at 0.2 mg/kg did not. Studies on the effects of these 4 drugs on conflict and conditioned behavior revealed that all exerted similar qual. effects, but quant. different actions.

Effects of a new minor tranquilizer, 10-chloro-3-methyl-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo [6,7]-1,4-diazepino[5,4-b]-oxazol-6-one (CS-386), on the after-discharge and behavior induced by electrical stimulation of the amygdala in freely moving cats: Effects of a new minor tranquilizer, 10-chloro-3-methyl-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo [6,7]-1,4-diazepino[5,4-b]-oxazol-6-one (CS-386), on the after-discharge and behavior induced by electrical stimulation of the amygdala in freely moving cats. Hasegawa, Kazuo; Ishibashi, Chieko (Cent. Res. Lab., Sankyo Co., Ltd., Tokyo, Japan). Nippon Yakurigaku Zasshi, 73(3), 287-95 (Japanese) 1977. CODEN: NYKZAU. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) CS-386 (I) [31868-18-5], cloxazolam, and oxazolam inhibited after-discharge (AD) induced by amygdaloid elec. stimulation in cats. I had the most potent inhibitory effect. Diazepam had no effects on the AD threshold, but decreased the AD duration and inhibited behavior. Chlordiazepoxide had no apparent effects on amygdaloid AD and on facial twitching. Salivation was inhibited with high doses. Phenobarbital shortened the AD duration and at a high dose elevated the AD threshold. This drug also inhibited salivation, but inhibitory effects on other behavior required doses as high as 90 mg/kg. Apparently, I is more potent than chlordiazepoxide, diazepam and phenobarbital, and acts on the amygdala itself.