3236-63-3

Basic information

• Product Name: 2,2'-METHYLENEBIS(4-METHYLPHENOL)
• Synonyms: 2,2'-DIHYDROXY-5,5'-DIMETHYLDIPHENYLMETHANE;2,2'-METHYLENEBIS(4-METHYLPHENOL);2,2'-METHYLENEBIS(P-CRESOL);2,2’-methylenebis[4-methyl-pheno;Methylenebismethylphenol);2,2'-methylenedi-p-cresol;2,2''-METHYLENEBIS(4-METHYLPHENOL) 90+%;2-(2-hydroxy-5-methyl-benzyl)-4-methyl-phenol
• CAS NO: 3236-63-3
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.29
• EINECS: 221-794-7
• Product Categories: Diphenylmethanes (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 3236-63-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 125°C
• Boiling Point: 386.3°Cat760mmHg
• Flash Point: 184.1°C
• Appearance: /
• Density: 1.151g/cm³
• PKA: 9.98±0.43(Predicted)
• CAS DataBase Reference: 2,2'-METHYLENEBIS(4-METHYLPHENOL)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-METHYLENEBIS(4-METHYLPHENOL)(3236-63-3)
• EPA Substance Registry System: 2,2'-METHYLENEBIS(4-METHYLPHENOL)(3236-63-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 3236-63-3(Hazardous Substances Data)

Usage

Uses

2,2''-Methylenebis(4-methylphenol) is used in preparation of bicyclic metal platinum(II) complexes with pyridazine derivative ligands application in organic electroluminescent devices.

Upstream product

• 50-00-0 formaldehyd 
• 106-44-5 p-cresol 
• 7205-91-6 phenylthiomethyl chloride 
• 119-47-1 2,2'-dihydroxy-5,5'-dimethyl-3,3'-di-tert-burtyl-1,1'-diphenylmethane 
• 56-23-5 tetrachloromethane 
• 67-66-3 chloroform 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 67-56-1 methanol 
• 4383-07-7 2-hydroxymethyl-4-methylphenol 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 

Downstream Products

• 118981-28-5 4,4'-dimethyl-6,6'-bis-morpholinomethyl-2,2'-methanediyl-di-phenol 
• 100030-60-2 6,6'-bis-dimethylaminomethyl-4,4'-dimethyl-2,2'-methanediyl-di-phenol 
• 54637-23-9 2-<2-(2-Hydroxy-5-methylbenzyl)-4-methylphenoxy>-ethanol 
• 114694-93-8 5,5'-Dimethyl-diphenylmethan-2,2'-bis-(2,4-dinitro-phenyl)-ether 
• 129758-73-2 6,6'-bis(bromomethyl)-4,4'-dimethyl-2,2'-methanediyldiphenol 
• 20837-68-7 6,6′-methylenebis(2-(2-hydroxy-5-methylbenzyl)-4-methylphenol) 
• 22247-58-1 2-(3-hydroxymethyl-2-hydroxy-5-methylbenzyl)-6-hydroxymethyl-4-methylphenol 
• 80678-92-8 3-(5-methylsalicyl)-5-methylsalicyl alcohol 
• 106-44-5 p-cresol 
• 527-60-6 Mesitol 
• 105-67-9 2,4-Xylenol 
• 855365-87-6 2-hydroxy-3-(2-hydroxy-5-methyl-benzyl)-5-methyl-benzoic acid 
• 56418-90-7 2,2'-dihydroxy-5,5'-dimethyl-3,3'-methanediyl-di-benzoic acid 
• 109-89-7 diethylamine 

Relevant articles and documents

Hydroxyalkylation of p-cresol to 2,2′-methylenebis(4-methylphenol) using Sn/Si-MCM-41 catalysts

Sn/Si-MCM-41 has exhibited an excellent catalytic activity [70% product yield with 88% selectivity to 2,2′-methylenebis(4methylphenol)] for the selective hydroxyalkylation of p-cresol. At equal level of Sn loading, Sn/Si-MCM-41 prepared by direct hydrothermal synthesis showed higher activity than Sn-impregnated Si-MCM-41 catalyst.

One-step novel synthesis of methylene bisphenols and methylene bisnaphthols using Lewis acid mediated rearrangement

Mono- and di-substituted isomeric methylene bisphenols and methylene bisnaphthols have been synthesized by rearrangement of the corresponding O-methoxyacetyl derivatives of phenols and naphthols, respectively, in presence of aluminium chloride under dry conditions. The chemistry observed is different from the usual Fries rearrangement reaction and involves an intermolecular rearrangement. The reactions reported here also reflect the influence of substituents present in the substrate as is supported by the substitution of the bridging methylene at a position meta to the phenolic hydroxyl in some of the minor products formed along-side the majorly formed ortho substituted products.

Synthesis of Monofunctionalized Calix[5]arenes

Seven OH-free and O -permethylated monofunctionalized calix[5]arenes carrying either additional methyl or tert -butyl groups are prepared following fragment condensation protocols. This strategy proves to be superior to previous approaches. Calix[5]arenes with free OH groups all adopt a cone conformation stabilized by a seam of hydrogen bonds at the lower rim. Post-condensation modifications, i.e., methylation of phenolic OH groups or functional group interconversions can also be achieved. Bulky tert -butyl groups are also found to stabilize the cone conformations of O -methylated compounds. These compounds offer versatile functional groups that make these concave molecules interesting building blocks for the synthesis of more sophisticated molecular architectures.