32377-36-9

Basic information

• Product Name: (4-chlorophenyl)(phenylamino)acetonitrile
• CAS NO: 32377-36-9
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.7035
• Mol File: 32377-36-9.mol
• Article Data: 99

Chemical Properties

• Boiling Point: 403.4°C at 760 mmHg
• Flash Point: 197.8°C
• Density: 1.262g/cm³
• Vapor Pressure: 1.02E-06mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: (4-chlorophenyl)(phenylamino)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl)(phenylamino)acetonitrile(32377-36-9)
• EPA Substance Registry System: (4-chlorophenyl)(phenylamino)acetonitrile(32377-36-9)

Safety Data

• Hazardous Substances Data: 32377-36-9(Hazardous Substances Data)

Usage

General Description

(4-chlorophenyl)(phenylamino)acetonitrile, also known as N-(4-chlorophenyl)benzene-1,2-diamine, is a chemical compound with the molecular formula C14H11ClN2. It is a nitrile compound and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical is often employed as an intermediate in the production of various organic compounds, including dyes, pigments, and other industrial chemicals. Additionally, it can also be utilized in research and development of new chemical processes and as a building block in organic synthesis. Due to its diverse applications, (4-chlorophenyl)(phenylamino)acetonitrile is an important and widely used chemical in various industries.

Upstream product

• 2179-92-2 tri-n-butyltin cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 62-53-3 aniline 
• 7677-24-9 trimethylsilyl cyanide 
• 2362-79-0 N-(4-chlorobenzylidene)aniline 
• 773837-37-9 sodium cyanide 
• 106-43-4 para-chlorotoluene 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 6413-52-1 2-(4-chloro-phenyl)-[1,3]dioxane 
• 2403-54-5 2-(4-chlorophenyl)-1,3-dioxolane 
• 151-50-8 potassium cyanide 
• 142-04-1 aniline hydrochloride 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 96524-01-5 anilino-(4-chloro-phenyl)-acetic acid amide 
• 4686-10-6 α-Anilino-α-4-chlorphenyl-N-phenylnitron 
• 1381802-26-1 4-amino-5-(4-chlorophenyl)-1,3-diphenyl-1H-pyrrol-2(5H)-one 
• 1381803-55-9 C₂₂H₁₇ClN₂O 
• 4750-61-2 N-(p-chlorobenzyl)aniline 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 72881-53-9 N-[1-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-2-oxo-ethyl]-N-phenyl-benzamide 
• 72867-63-1 N-[1-(4-Chloro-phenyl)-1-cyano-2-phenyl-ethyl]-N-phenyl-benzamide 
• 72867-75-5 2-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-2-phenylamino-ethanone 
• 52827-08-4 4-(4-chloro-phenyl)-3-phenyl-sydnone 
• 73842-44-1 2-(4-chlorophenyl)-N-phenylglycine 
• 54615-66-6 α-phenylimino-p-chlorophenylacetonitrile 

Relevant articles and documents

Catalytic Strecker reaction: g-C3N4-anchored sulfonic acid organocatalyst for the synthesis of α-aminonitriles

Abstract: Efficient organocatalyst for enantioselective Strecker reaction was synthesized using g-C3N4 sheets (CN). CN-anchored sulfonic acid (CN-Bu-SO3H) was found to be a highly efficient and recoverable organocatalyst f

Nitrile compound catalytic synthesis method and application thereof

The invention relates to the technical field of chemical catalytic synthesis, and particularly discloses a nitrile compound catalytic synthesis method and application thereof. According to the nitrile compound catalytic synthesis method, an alpha-aminonitrile or alpha-imino nitrile compound can be synthesized through selective reaction. The nitrile compound catalytic synthesis method has the advantages of simple and easily available raw materials, wide substrate applicability, mild conditions, high yield and the like, the yield is superior to that of a traditional chemical synthesis method, and the nitrile compound catalytic synthesis method is suitable for industrial production. The problems that an existing synthesis method of alpha-aminonitrile and alpha-imino nitrile compounds is not high in yield and does not meet the requirement of green chemistry are solved. Moreover, compared with a traditional chemical synthesis method, a heme system is more efficient and green in use, a substrate is simple and easy to obtain, a tedious catalysis step is not needed, a low-toxicity cyano donor is used, the substrate is wide in applicability, the requirement of green chemistry is met, and the heme system has a wide market prospect.

Fe3O4?SiO2 nanoparticles–functionalized Cu(II) Schiff base complex with an imidazolium moiety as an efficient and eco-friendly bifunctional magnetically recoverable catalyst for the Strecker synthesis in aqueous media at room temperature

Cu(II) Schiff base complex supported on Fe3O4?SiO2 nanoparticles was employed as a magnetic nanocatalyst (nanocomposite) with a phase transfer functionality for the one-pot preparation of α-aminonitriles (Strecker reaction). The desired α-aminonitriles were obtained from the reaction of aromatic or aliphatic aldehydes, aniline or benzyl amine, NaCN, and 1.6 mol% of the catalyst in water at room temperature and good to excellent yields were obtained for all substrates. The catalyst was characterized analytically and instrumentally including Fourier-transform infrared spectroscopy, X-ray diffraction, thermogravimetric, nuclear magnetic resonance, energy-dispersive X-ray spectroscopy, inductively coupled plasma spectroscopy, vibrating-sample magnetometry analysis, dynamic light scattering, Brunauer–Emmett–Teller surface area, field emission scanning electron microscopy, and transmission electron microscopy analyses. The reaction mechanism was investigated, in which the performance of the catalyst as a phase transition factor seems to be probable. The catalyst showed high activity, high turnover frequency (TOF)s, significant selectivity, and fast performance toward the Strecker synthesis. The nanocatalyst can be readily and quickly separated from the reaction mixture with an external magnet and can be reused for at least seven successive reaction cycles without significant reduction in efficiency.