324523-20-8
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Basic information
- Product Name: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
- Synonyms: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride;NPS-2143 HCL;NPS-2143 (Mono HCl);2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1);SB-262470-A hydrochloride;NPS2143 hydrochloride, >=98%
- CAS NO:324523-20-8
- Molecular Formula: C24H25ClN2O2.HCl
- Molecular Weight: 445.38144
- EINECS: N/A
- Product Categories: N/A
- Mol File: 324523-20-8.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white to beige/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: >10mg/mL
- CAS DataBase Reference: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride(324523-20-8)
- EPA Substance Registry System: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride(324523-20-8)
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Safety Data
- Hazard Codes: Xn,N
- Statements: 20/21/22-50/53
- Safety Statements: 36/37-60-61
- RIDADR: UN 3077 9 / PGIII
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 324523-20-8(Hazardous Substances Data)
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324523-20-8 Usage
Description
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM). It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously. Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.Biochem/physiol Actions
NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.Check Digit Verification of cas no
The CAS Registry Mumber 324523-20-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,4,5,2 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.Calculate Digit Verification of CAS Registry Number 324523-20:
(8*3)+(7*2)+(6*4)+(5*5)+(4*2)+(3*3)+(2*2)+(1*0)=108
108 % 10 = 8
So 324523-20-8 is a valid CAS Registry Number.
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2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
