32477-35-3

Basic information

• Product Name: N-Heptafluorobutyrylimidazole
• Synonyms: N-(HEPTAFLUORO-N-BUTYRYL)IMIDAZOLE;N-HEPTAFLUOROBUTANOYLIMIDAZOLE;N-HEPTAFLUOROBUTYRYLIMIDAZOLE;N-Heptafluorobutyryl-imidazole 98+;1-(Heptafluorobutyryl)imidazole, 98+%;1-(Heptafluorobutyryl)imidazole,1-(Perfluorobutyryl)imidazole;1-(Perfluorobutanoyl)-1H-imidazole 97%;1-(Perfluorobutanoyl)-1H-imidazole 99+%
• CAS NO: 32477-35-3
• Molecular Formula: C₇H₃F₇N₂O
• Molecular Weight: 264.1
• EINECS: 251-063-8
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Labeling and Diagnostics Reagents;Pharmaceuticals;Acylation Reagent;Imidazol&Benzimidazole;Acylation (GC Derivatizing Reagents);Analytical Chemistry;GC Derivatizing Reagents;Acylation ReagentsBiochemicals and Reagents;Derivatization agentsBuilding Blocks;Analytical/Chromatography;Derivatization Reagents;Heterocyclic Building Blocks;Imidazoles;Luminescent Compounds/Detection
• Mol File: 32477-35-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 9-13 °C
• Boiling Point: 161 °C(lit.)
• Flash Point: 171 °F
• Appearance: /
• Density: 1.490 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000762mmHg at 25°C
• Refractive Index: n20/D 1.3865(lit.)
• Storage Temp.: −20°C
• Solubility: Miscible with chloroform and methanol.
• PKA: 1.37±0.10(Predicted)
• Sensitive: Hygroscopic
• Stability: Moisture Sensitive
• BRN: 4488026
• CAS DataBase Reference: N-Heptafluorobutyrylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: N-Heptafluorobutyrylimidazole(32477-35-3)
• EPA Substance Registry System: N-Heptafluorobutyrylimidazole(32477-35-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• F: 3-10-21
• HazardClass: IRRITANT, MOISTURE SENSITIVE, KE
• Hazardous Substances Data: 32477-35-3(Hazardous Substances Data)

Usage

Chemical Properties

N-Heptafluorobutyrylimidazole is colorless liquid

Uses

Different sources of media describe the Uses of 32477-35-3 differently. You can refer to the following data:
1. 1-(Heptafluorobutyryl)imidazole is used in gas chromatography for the determination of various pharmaceutical compounds like retronecine in biological matrixes. It acts as a reagent for derivatize amine-groups. It plays an essential role to reduce GC column degradation due to its non-acidic property. It is an acylating agent, which converts thermally unstable compounds to its more volatile derivative and then made suitable for GC analysis.
2. N-Heptafluorobutyrylimidazole is a derivatization agent used in gas chromatography for determination of various pharmaceutical compounds such as retronecine in biological matrixes.

General Description

May form a precipitate and may darken on storage-will not effect performance.

Biochem/physiol Actions

Mild amine-group derivatizing reagent; non-acidic by-product prevents decomposition and reduces GC column degradation.

InChI:InChI=1/C12H10FN.ClH/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10;/h1-8H,14H2;1H

Upstream product

• 288-32-4 1H-imidazole 
• 336-59-4 heptafluorobutyric anhydride 
• 375-22-4 heptafluorobutyric Acid 

Downstream Products

• 288-32-4 1H-imidazole 
• 950908-47-1 2-heptafluorobutyrylcyclohexane-1,3-dione 
• 950908-46-0 2-heptafluorobutyryl-5,5-dimethylcyclohexane-1,3-dione 
• 70473-77-7 2,2,3,3,4,4,4-Heptafluoro-butyric acid 2-(2,2,3,3,4,4,4-heptafluoro-butyrylamino)-ethyl ester 

Relevant articles and documents

Synthesis of novel 2-perfluoroacylcyclohexane-1,3-diones

A one-pot synthesis of 2-perfluoroalkanoylcyclohexane-1,3-diones via C-acylation of cyclohexane-1,3-diones with N-perfluoroacylimidazole as an acylating agent is reported. A reaction was examined with isolated N-trifluoroacetylimidazole and with N-perfluoroacylimidazoles generated in situ from perfluorocarboxylic acid anhydrides or perfluorocarboxylic acids.