Reference

Quantitative gas-liquid chromatography of amphetamine, ephedrine, codeine and morphine after on-column acylation

Quantitative gas-liquid chromatography of amphetamine, ephedrine, codeine and morphine after on-column acylation. Brugaard, Gunhild; Rasmussen, Knut E. (Inst. Pharm., Univ. Oslo, Oslo, Norway). J.There are some reagents like 66091-19-8 is used in this study. Chromatogr., 147, 476-80 (English) 1978. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 9, 80 On-column acylation of amphetamine [300-62-9], ephedrine [299-42-3], codeine [76-57-3], and morphine [57-27-2], with either N-(trifluoroacetyl)imidazole (I) [1546-79-8] or N-(heptafluorobutyryl)imidazole (II) [32477-35-3], provided a rapid and accurategas chromatog. method for the quant. detn. of these drugs. The results were reproducible, and the acylating potential of the reagents was not seriously affected by possible decompn. and contamination. In general II gave a more stable acylation product than I. .

Analysis of the sulphur mustard metabolites thiodiglycol and thiodiglycol sulphoxide in urine using isotope-dilution gas chromatography-ion trap tandem mass spectrometry

All Rights Reserved. Analysis of the sulphur mustard metabolites thiodiglycol and thiodiglycol sulphoxide in urine using isotope-dilution gas chromatography-ion trap tandem mass spectrometry. Riches, James; Read, Robert W.; Black, Robin M. (Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 0JQ, UK). Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 845(1), 114-120 (English) 2007 Elsevier B.V. CODEN: JCBAAI. ISSN: 1570-0232. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A sensitive method was developed for the trace anal. of the sulfur mustard metabolite thiodiglycol (TDG) in urine, and its oxidn. product thiodiglycol sulfoxide (TDGO) after redn. to thiodiglycol. Thiodiglycol was extd. from urine by solid phase extn. onto a polymeric cartridge and, after isolation, converted to its bis-heptafluorobutyryl deriv. with heptafluorobutyryl imidazole. An ion trap mass spectrometer in selected reaction monitoring mode detected spiked concns. down to 0.2 ng/mL with a signal to noise ratio > 3:1. Urine, from human volunteers with no known exposure to sulfur mustard, contained detectable but very low concns. (<0.2 ng/mL) of thiodiglycol, consistent with previous observations using different methodologies. Combined concns.There are some commonly used reagents with their cas registry numbers 7705-07-9 and 32477-35-3 in this article. of thiodiglycol and thiodiglycol sulfoxide were detd. after redn. of the latter with titanium trichloride. In this case higher background levels (up to 3 ng/mL) were obsd., consistent with the sulfoxide being the major excretion product of the two metabolites. The method was applied to urine samples, stored frozen for 13 years, from 2 casualties of accidental mustard poisoning. Levels of thiodiglycol were 1 and 3 ng/mL, which increased to 78 and 104 ng/mL after treatment of the urine with titanium trichloride. .