32891-88-6

Basic information

• Product Name: Naphthalene, 1-[(4-methoxyphenyl)methyl]-
• CAS NO: 32891-88-6
• Molecular Formula: C18H16O
• Molecular Weight: 248.324
• Mol File: 32891-88-6.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Naphthalene, 1-[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene, 1-[(4-methoxyphenyl)methyl]-(32891-88-6)
• EPA Substance Registry System: Naphthalene, 1-[(4-methoxyphenyl)methyl]-(32891-88-6)

Safety Data

• Hazardous Substances Data: 32891-88-6(Hazardous Substances Data)

Upstream product

• 6245-96-1 α-naphthylmethyl phenyl ether 
• 100-66-3 methoxybenzene 
• 28942-32-7 4-(naphthalen-1-ylmethyl)phenol 
• 74-88-4 methyl iodide 
• 108-95-2 phenol 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 91-20-3 naphthalene 
• 824-94-2 p-methoxybenzyl chloride 
• 703-55-9 1-naphthylmagnesiumbromide 
• 38274-80-5 dimethyl(naphthalen-1-yl)silane 
• 5720-07-0 4-methoxyphenylboronic acid 
• 72681-59-5 1-naphthylmethyl 2,2-dimethylpropanoate 
• 13922-41-3 1-Naphthylboronic acid 
• 6844-18-4 (4-methoxyphenyl)(naphthalen-1-yl)methanol 

Downstream Products

• 39070-92-3 (4-methoxyphenyl)(naphthalen-1-yl)methanone 

Relevant articles and documents

The effect of co-catalyst in the Friedel-Crafts reaction in synthesis of diaryl-naphth-1-yl-methane derivatives

Synthesis of substituted diaryl-naphth-1-yl-methane has been carried out by Friedel-Crafts reaction of aryl naphth-1-yl methanol with substituted phenols. During the course of this reaction using AlCl3 as catalyst some rearrangements occurred,

Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides

The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl2(dppf)2 associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug molecules. Graphical abstract: [Figure not available: see fulltext.]

Ligand-Facilitated Reductive Coupling of Benzyl Chlorides with Aryl Chlorides Catalyzed by Well-Defined Heteroleptic Ni (II)-NHC Complexes

Novel heteroleptic Ni (II) complexes bearing a highly hindered yet flexible IPr* ligand, Ni (IPr*)(PPh3)Br2 (1) and Ni (IPr*)(PCy3)Br2 (2) (IPr* = 1,3-bis(2,6-bis (diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene), were easily prepared in 78percent and 89percent yield, respectively. Both were characterized by elemental analysis and NMR spectroscopy, and 1 was subjected to X-ray crystallography. Compared with 2 and its analogue bearing a less sterically demanding IPr ligand (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), complex 1 exhibited superior catalytic activity in the magnesium-mediated reductive coupling of benzyl chlorides with aryl chlorides, featuring outstanding tolerance of both coupling partners with steric demand. This study discloses a ligand-facilitated reductive coupling of benzyl chlorides with aryl chlorides, which provides a new and practical synthetic tool for the synthesis of diarylmethanes.

Cross coupling of benzylammonium salts with boronic acids using a well-defined N-heterocyclic carbene-palladium(ii) precatalyst

N-heterocyclic carbene-palladium(ii)-catalyzed cross-coupling of benzylammonium salts with arylboronic acids for the synthesis of diarylmethane derivatives via C-N bond activation has been developed. Notably, in the presence of the easily prepared and bench-stable Pd-PEPPSI precatalyst, the Csp3-N bond activation of the benzylammonium salt even proceeded smoothly in isopropanol at room temperature.