33172-54-2

Basic information

• Product Name: 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE
• Synonyms: 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE;3-Bromo-5-methylsalicylaldehyde
• CAS NO: 33172-54-2
• Molecular Formula: C₈H₇BrO₂
• Molecular Weight: 215.04
• Mol File: 33172-54-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE(33172-54-2)
• EPA Substance Registry System: 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE(33172-54-2)

Safety Data

• Hazardous Substances Data: 33172-54-2(Hazardous Substances Data)

Usage

Description

3-Bromo-2-hydroxy-5-methyl-benzaldehyde, with the CAS number 33172-54-2, is an organic compound belonging to the class of aromatic aldehydes. It features a bromine atom at the 3rd position, a hydroxyl group at the 2nd position, and a methyl group at the 5th position on a benzene ring. 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE is known for its distinct chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
3-Bromo-2-hydroxy-5-methyl-benzaldehyde is used as a reagent for the preparation of flavone derivatives, which are essential in the treatment and prophylaxis of hepatitis B virus disease. 3-BROMO-2-HYDROXY-5-METHYL-BENZALDEHYDE plays a crucial role in the synthesis of these therapeutic agents, contributing to the development of effective medications against hepatitis B.

Upstream product

• 50-00-0 formaldehyd 
• 6627-55-0 2-bromo-p-cresol 
• 67-66-3 chloroform 
• 60-29-7 diethyl ether 
• 7726-95-6 bromine 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 106-44-5 p-cresol 

Downstream Products

• 1000414-97-0 N-(3-bromo-5-methylsalicylidene)-3-[bis(5-methyl-2-furyl)methyl]aniline 
• 1032506-48-1 2-bromo-6-cyano-4-methylphenol 
• 1619925-29-9 3-bromo-5-methylsalicylaldehyde rhodamine B hydrazone 
• 708209-60-3 C₂₂H₂₄Br₂N₂O₂ 
• 1247212-21-0 8-bromo-6-methyl-3-(3,4,5-trimethoxyphenyl)coumarin 
• 1247212-20-9 8-bromo-6-methyl-3-(3,5-dimethoxyphenyl)coumarin 
• 1247212-14-1 8-bromo-6-methyl-3-phenylcoumarin 

Relevant articles and documents

Facile one-pot transformation of phenols into o-cyanophenols

The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.

New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors

With the aim to find out the structural features for the MAO inhibitory activity and selectivity, in the present communication we report the synthesis and pharmacological evaluation of a new series of bromo-6-methyl-3- phenylcoumarin derivatives (with bro

2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.