33420-83-6

Basic information

• Product Name: Ethanone, 2-(4-methoxyphenyl)-1-[4-(methylsulfonyl)phenyl]-
• CAS NO: 33420-83-6
• Molecular Formula: C16H16O4S
• Molecular Weight: 304.367
• Mol File: 33420-83-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(4-methoxyphenyl)-1-[4-(methylsulfonyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-methoxyphenyl)-1-[4-(methylsulfonyl)phenyl]-(33420-83-6)
• EPA Substance Registry System: Ethanone, 2-(4-methoxyphenyl)-1-[4-(methylsulfonyl)phenyl]-(33420-83-6)

Safety Data

• Hazardous Substances Data: 33420-83-6(Hazardous Substances Data)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 33420-82-5 2-(4-methoxy-phenyl)-1-(4-methylsulfanyl-phenyl)ethanone 

Downstream Products

• 1542256-76-7 5-(4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine 
• 1542256-66-5 C₁₆H₁₅NO₅S 
• 1542256-71-2 C₁₇H₁₅N₃O₃S₂ 
• 877224-40-3 C₁₇H₁₉N₃O₄S 

Relevant articles and documents

Design, synthesis and in vitro study of 5,6-diaryl-1,2,4-triazine-3-ylthioacetate derivatives as COX-2 and β-amyloid aggregation inhibitors

In order to find novel cyclooxygenase (COX)-2 inhibitors for treating inflammatory-based diseases such as Alzheimer's disease (AD), an ethyl carboxylate side chain was added to 5-(4-chlorophenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine

Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: A novel class of cyclooxygenase-2 inhibitors

A series of 2-trifluoromethyl/sulfonamido-5,6-diarylsubstituted imidazo[2,1-b]-1,3,4-thiadiazole derivatives 15a-j have been synthesized by the reaction of 2-amino-5-trifluoromethyl/sulfonamido-1,3,4-thiadiazoles 14a-b and appropriately substituted α-bromo-1,2-(p-substituted)diaryl-1-ethanones 13a-h. Structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass, and HRMS data. The selected compounds were evaluated for their preliminary in vitro cyclooxygenase inhibitory activity against COX-2 and COX-1enzymes using colorimetric method. The compounds tested showed selective inhibitory activity toward COX-2 (80.6-49.4%) over COX-1 (30.6-8.6), amongst them compounds 15f and 15j showed appreciable COX-2 selective inhibitory activity. These compounds also exhibited significant anti-inflammatory activity (70.09-42.32%), which is comparable to that of celecoxib in the carrageenan-induced rat paw edema method.