334952-07-7

Basic information

• Product Name: Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate
• Synonyms: Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate;4-(Methoxycarbonyl)-2-nitrobenzeneacetic acid methyl ester;Methyl 2-(4-Methoxycarbonyl-2-nitrophenyl)acetate;4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester
• CAS NO: 334952-07-7
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253
• Mol File: 334952-07-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 77℃
• Boiling Point: 370℃
• Flash Point: 163℃
• Appearance: /
• Density: 1.318
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate(334952-07-7)
• EPA Substance Registry System: Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate(334952-07-7)

Safety Data

• Hazardous Substances Data: 334952-07-7(Hazardous Substances Data)

Usage

General Description

Methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate is a chemical compound that belongs to the class of organic compounds known as nitrobenzoates. It is a derivative of 3-nitrobenzoic acid and is commonly used in organic synthesis and as a building block for the preparation of various pharmaceuticals and agrochemicals. methyl 4-(2-methoxy-2-oxoethyl)-3-nitrobenzoate has a methyl ester functional group at the 4-position, a nitro group at the 3-position, and a 2-methoxy-2-oxoethyl substituent at the 4-position of the benzene ring. It may have applications in the field of chemical research and drug development due to its versatile chemical structure and reactivity.

Upstream product

• 121-92-6 3-nitrobenzoic acid 
• 865-47-4 potassium tert-butylate 
• 618-95-1 methyl 3-nitrobenzoate 
• 96-34-4 methyl chloroacetate 
• 651747-69-2 2-(4-cyano-2-nitrophenyl)malonic acid dimethyl ester 
• 89642-49-9 4-bromo-3-nitrobenzonitrile 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 501-89-3 4-(carboxymethyl)benzoic acid 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 67-56-1 methanol 
• 444667-11-2 2-(4-carboxy-2-nitrophenyl)-acetic acid 

Downstream Products

• 1160293-25-3 methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate 
• 1160293-24-2 N-chloroacetyl-3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 
• 1160293-22-0 3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylic acid methyl ester 
• 656247-17-5 nintedanib 
• 1027407-75-5 (Z)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 
• 334952-09-9 2-Oxo-2,3-dihydro-1H-indole-6-carboxylic acid 
• 1105512-80-8 methyl 2-(4-methoxycarbonyl-2-nitrophenyl)acrylate 

Relevant articles and documents

Indolone derivative and pharmaceutical application thereof

The invention provides an indolone derivative and pharmaceutical application thereof. The structure of the indolone derivative is shown as a formula (A). Experimental results show that the compound provided by the invention has obviously improved pharmacokinetic properties than BIBF1120, has excellent inhibition effects on VEGFR, FGFR and PDGFR, can be used as a VEGFR, FGFR and/or PDGFR inhibitor,an angiogenesis inhibitor and a drug for preventing and/or treating various tumors including pharyngeal squamous cell carcinoma, and has a wide application prospect.

OXINDOLE INHIBITORS OF TYROSINE KINASE

The present invention relates to new oxindole inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.

Substituted indolines which inhibit receptor tyrosine kinases

Indolinones of the formula having an inhibitory effect on receptor tyrosine kinases and cyclin/CDK complexes, as well as on the proliferation of endothelial cells and various tumor cells. Exemplary are: (a) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-ethoxycarbonyl-2-indolinone, (b) 3-Z-[(1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-carbamoyl-2-indolinone, and (c) 3-Z-[1-(4-(piperidin-1-yl-methyl)-anilino)-1-phenyl-methylene]-6-metboxycarbonyl-2-indolinone.