334952-09-9

Basic information

• Product Name: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BO 0984;OXINDOLE-6-CARBOXYLIC ACID;2,3-DIHYDRO-2-OXO-1H-INDOLE-6-CARBOXYLIC ACID;2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID;6-OXINDOLECARBOXYLIC ACID;6-CARBOXYOXINDOLE;2-Oxo-indoline-6-carboxylic acid;2,3-Dihydro-2-oxo-1H-indole-6-carboxylic acid97%
• CAS NO: 334952-09-9
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Product Categories: blocks;Carboxes;IndolesOxindoles;pharmacetical;Indoline & Oxindole
• Mol File: 334952-09-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 438.1 °C at 760 mmHg
• Flash Point: 218.8 °C
• Appearance: /
• Density: 1.433 g/cm³
• Vapor Pressure: 1.89E-08mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.94±0.20(Predicted)
• CAS DataBase Reference: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID(334952-09-9)
• EPA Substance Registry System: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID(334952-09-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 334952-09-9(Hazardous Substances Data)

Usage

General Description

2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID, also known as Isatin-3-carboxylic acid, is a chemical compound with a molecular formula C9H7NO3. It is a derivative of the heterocyclic compound indole, and is commonly used in the synthesis of pharmaceuticals and other organic compounds. It is known for its potential therapeutic properties and has been studied for its anti-inflammatory, anti-cancer, and anti-microbial activities. The compound has also been investigated for its potential use in the treatment of neurodegenerative diseases and mental disorders. Isatin-3-carboxylic acid is a versatile building block in organic synthesis, and its derivatives have been explored for various medicinal and industrial applications.

InChI:InChI=1/C9H7NO3/c11-8-4-5-1-2-6(9(12)13)3-7(5)10-8/h1-3H,4H2,(H,10,11)(H,12,13)

Upstream product

• 101870-10-4 2,3-dicarbonylindolone-6-carboxylic acid 
• 99-05-8 meta-aminobenzoic acid 
• 954239-49-7 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester 
• 14192-26-8 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 
• 444667-11-2 2-(4-carboxy-2-nitrophenyl)-acetic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 334952-07-7 4-methoxycarbonylmethyl-3-nitrobenzoic acid methyl ester 
• 501-89-3 4-(carboxymethyl)benzoic acid 
• 121-92-6 3-nitrobenzoic acid 

Downstream Products

• 1401461-12-8 N-(1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)pyrrolidin-3-yl)-2-oxoindoline-6-carboxamide 

Relevant articles and documents

Method for preparing methyl 2-carbonyloxindole-6-carboxylate

The invention relates to a novel method for preparing methyl 2-carbonyloxindole-6-carboxylate. The method has the advantages of simple processes, high yield and mass production.

Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3. X-ray crystallographic structures aided in the design and synthesis of novel, selective compounds, that inhibit JNK3, but not p38 MAP kinase and provided key insights into understanding the behavior of gatekeeper residue methionine-146 in determining target selectivity for this series.

INDOLINONES AND THEIR USE AS ANTIPROLIFERATIVE AGENTS

The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.