334981-11-2

Basic information

• Product Name: 4-(1-Pyrrolidinylsulforylmenthyl)phenylhydrazine hydrochloride
• Synonyms: 1-[[(4-Hydrazinylphenyl)methyl]sulfonyl]pyrrolidine hydrochloride;4-(1-Pyrrolidinylsulforylmenthyl)phenylhydrazine hydrochloride;4-(1-PYRROLIDINYLSULFORYLMENTHYL)PHENYLHYDRAZINE HCL;1-((4-(Hydrazino)benzeneMethane)sulfonyl)pyrrolidine Hydrochloride;1-[[(4-Hydrazinophenyl)Methyl]sulfonyl]pyrrolidine Hydrochloride;4-(Pyrrolidino Sulfonyl Methyl) Phenyl Hydrazine Dihcl;1-((4-Hydrazinylbenzyl)sulfonyl)-pyrrolidine hydrochloride;AlMotriptan Hydrazine Precursor HCl
• CAS NO: 334981-11-2
• Molecular Formula: C₁₁H₁₇N₃O₂S*ClH
• Molecular Weight: 291.8
• EINECS: 1806241-263-5
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 334981-11-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 470.3 °C at 760 mmHg
• Flash Point: 238.2 °C
• Appearance: /
• Vapor Pressure: 5.14E-09mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 4-(1-Pyrrolidinylsulforylmenthyl)phenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-Pyrrolidinylsulforylmenthyl)phenylhydrazine hydrochloride(334981-11-2)
• EPA Substance Registry System: 4-(1-Pyrrolidinylsulforylmenthyl)phenylhydrazine hydrochloride(334981-11-2)

Safety Data

• Hazardous Substances Data: 334981-11-2(Hazardous Substances Data)

Usage

Uses

Almotriptan intermediate

InChI:InChI=1/C11H17N3O2S.ClH/c12-13-11-5-3-10(4-6-11)9-17(15,16)14-7-1-2-8-14;/h3-6,13H,1-2,7-9,12H2;1H

Upstream product

• 1112206-13-9 1-(4-amino-benzenemethanesulfonyl)pyrrolidine hydrochloride 
• 334981-10-1 4-((pyrrolidin-1-ylsulfonyl)methyl)aniline 

Downstream Products

• 1020765-97-2 d2-4-[2-[4-(dimethylamino)butylidene]hydrazinyl]-benzylsulfonylpyrrolidine 
• 1364283-62-4 C₂₂H₂₂F₃N₃O₂S 
• 1364283-57-7 C₂₁H₂₀F₃N₃O₂S 
• 1364283-51-1 3-methyl-1-(4-((pyrrolidin-1-ylsulfonyl)methyl)phenyl)-5-(thiophen-2-yl)-1H-pyrazole 

Relevant articles and documents

Synthesis of n-methyl benzenemethane sulfonamide substituted carbazoles and pyrazoles

Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data.

PREPARATION AND UTILITY OF SUBSTITUTED INDOLES

Disclosed herein are substituted indoles of Formula I, processes of preparation there of, pharmaceutical compositions thereof, and methods of their use there of.

Synthesis of 5-(sulfamoylmethyl)indoles

The synthesis of 5-(sulfamoylmethyl)indoles bearing a two-carbon chain at C-3 (aminoethyl, acetate, hydroxyethyl, ethyl) either by the Grandberg modification of the Fischer indolization or by intramolecular Heck reaction of suitable o-halotrifluoroacetanilides is reported.