3367-48-4

Basic information

• Product Name: 1,4-bis(4-methylphenyl)piperazine
• CAS NO: 3367-48-4
• Molecular Formula: C₁₈H₂₂N₂
• Molecular Weight: 266.3807
• Mol File: 3367-48-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 441.6°C at 760 mmHg
• Flash Point: 201.4°C
• Density: 1.067g/cm³
• Vapor Pressure: 5.39E-08mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 1,4-bis(4-methylphenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-bis(4-methylphenyl)piperazine(3367-48-4)
• EPA Substance Registry System: 1,4-bis(4-methylphenyl)piperazine(3367-48-4)

Safety Data

• Hazardous Substances Data: 3367-48-4(Hazardous Substances Data)

Usage

Chemical Class

Piperazine

Structure

Piperazine ring with two 4-methylphenyl groups attached

Potential Use

Pharmaceutical industry

Application

Central nervous system stimulant

Additional Investigation

Drug precursor

Effects

Stimulant effects on the central nervous system

Importance

Further research and exploration in pharmaceuticals and chemical precursors

Upstream product

• 2933-74-6 2-[(4-methylphenyl)amino]-ethanol 
• 106-49-0 p-toluidine 
• 106-93-4 ethylene dibromide 
• 108-88-3 toluene 
• 110-85-0 piperazine 
• 106-43-4 para-chlorotoluene 
• 107-21-1 ethylene glycol 
• 106-38-7 para-bromotoluene 
• 107-06-2 1,2-dichloro-ethane 
• 6315-52-2 1,2-bis-tosyloxyethane 
• 107-07-3 2-chloro-ethanol 
• 127-09-3 sodium acetate 
• 7025-90-3 N, N’-dimethyl-N,N’-di-p-tolylethane-1,2-diamine 
• 75-21-8 oxirane 

Relevant articles and documents

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β-Amino alcohols from anilines and ethylene glycol through heterogeneous Borrowing Hydrogen reaction

Borrowing Hydrogen (BH), also called Hydrogen Autotransfer (HA), reaction with neat ethylene glycol represents a key step in the preparation of β-amino alcohols. However, due to the stability of ethylene glycol, mono-activation has rarely been achieved. Herein, a combination of Pd/C and ZnO is reported as heterogeneous catalyst for this BH/HA reaction. This system results in an extremely air and moisture stable, and economic catalyst able to mono-functionalize ethylene glycol in water, without further activation of the diol. In this work, different diols and aromatic amines have been explored affording a new approach towards amino alcohols. This study reveals how the combination of two solid species can afford interesting catalytic properties in heterogeneous phase. ZnO activates ethylene glycol while Pd/C is the responsible of the BH/HA cycle. This catalytic system has also been found useful to dehydrogenate indoles affording indolines that undergo in situ BH/HA cycle prior to re-aromatization, representing a tandem heterogeneous process.

Microwave-promoted mono-N-alkylation of aromatic amines in water: A new efficient and green method for an old and problematic reaction

A greener improvement to direct mono-N-alkylation of aromatic amines by alkyl halides was achieved using microwave irradiation in water without any catalyst.