33854-16-9Relevant articles and documents
Schneider,Murray
, p. 397 (1973)
Conversion of arachidonic acid to the prostaglandin endoperoxide PGG2, a chemical analog of the biosynthetic pathway
Corey,Wang, Zhe
, p. 539 - 542 (1994)
Reaction of the methyl ester of (15S)-hydroperoxy-5,8-11Z-13E-eicosapentaenoic acid (7) with oxygen in benzene solution in the presence of a catalyst made from samarium (II) iodide and O2 produces a mixture of the methyl esters of PGG2 (12) and its 12-epimer (15) (ratio 1:3, yield 43% based on recovered starting material).
Cyclopentane 1-hydroxy alkyl or alkenyl-2-one or 2-hydroxy derivatives as therapeutic agents
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Page column 8, (2010/01/31)
The present invention provides a novel compound represented by the general formula I; wherein R is H or COR3; R1is H, R2, phenyl, or COR3, wherein R2is C1-C5lower alkyl and R3is R2or phenyl; Z is CH2or O; Y is OH, OCOR3or ═O; x is 0 or 1; and X is C1-C5n-alkyl, C3-C7cycloalkyl, phenyl, furanyl, thienyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5alkyl, halogen, CF3, CN, NO2, NR42, CO2R4and OR4wherein R4is hydrogen or C1-C5alkyl and dotted lines represent the presence or absence of a double bond and wavy lines represent a cis or trans bond. These novel compounds are especially useful for treating elevated intraocular pressure (ocular hypertension) and glaucoma.
Design and synthesis of 13,14-dihydro prostaglandin F(1α) analogues as potent and selective ligands for the human FP receptor
Wang, Yili,Wos, John A.,Dirr, Michelle J.,Soper, David L.,DeLong, Mitchell A.,Mieling, Glen E.,De, Biswanath,Amburgey, Jack S.,Suchanek, Eric G.,Taylor, Cynthia J.
, p. 945 - 952 (2007/10/03)
The in vitro evaluation of a new class of potential bone anabolic agents for the treatment of osteoporosis is described. These compounds are potent and selective ligands for the human prostaglandin F receptor (hFP receptor). The compounds lack the olefin unsaturation required for potency in the natural ligand PGF(2α) yet retain binding affinity for the hFP receptor in the nanomolar to micromolar range. Removal of the alkenes also results in a better selectivity ratio for the hFP receptor over the other prostaglandin receptors tested. A rationale for the selectivity differences of various analogues, based on ligand docking experiments to a putative hFP receptor model, is also described.
