33863-82-0

Basic information

• Product Name: 4-methyl-N-(1-phenylethyl)aniline
• CAS NO: 33863-82-0
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.3022
• Mol File: 33863-82-0.mol
• Article Data: 66

Chemical Properties

• Boiling Point: 322.9°C at 760 mmHg
• Flash Point: 153.3°C
• Density: 1.04g/cm³
• Vapor Pressure: 0.000271mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 4-methyl-N-(1-phenylethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(1-phenylethyl)aniline(33863-82-0)
• EPA Substance Registry System: 4-methyl-N-(1-phenylethyl)aniline(33863-82-0)

Safety Data

• Hazardous Substances Data: 33863-82-0(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 540-23-8 p-toluidine hydrochloride 
• 106-49-0 p-toluidine 
• 917-64-6 methyl magnesium iodide 
• 2272-45-9 benzal-p-toluidine 
• 6749-54-8 1-phenylethyl p-toluenesulfonate 
• 114200-14-5 1-phenylethyl p-nitrobenzenesulfonate 
• 4209-15-8 N-(1-phenyl-ethylidene)-p-toluidine 
• 98-86-2 acetophenone 
• 106-38-7 para-bromotoluene 
• 618-36-0 rac-methylbenzylamine 
• 100-41-4 ethylbenzene 
• 98-85-1 1-Phenylethanol 
• 536-74-3 phenylacetylene 

Downstream Products

• 72209-52-0 1-(1-phenylethyl)naphthalen-2-ol 
• 70660-38-7 rac-4-methyl-2-sec-phenethylaniline 

Relevant articles and documents

Acid-catalyzed ortho-alkylation of anilines with styrenes: An improved route to chiral anilines with bulky substituents

(Chemical Equation Presented) Reaction of para-substituted anilines with styrene derivatives at elevated temperatures, when catalyzed by CF 3SO3H, results in highly chemoselective ortho-alkylation of the aniline. When R = H, dialkylation can be achieved by varying the ratio of styrene to aniline. Several different substituted anilines and styrenes were examined, and good yields (42-87%) were obtained, except in the case where electron-withdrawing substituents are present on the styrene.

Palladium supported on magnesium hydroxyl fluoride: An effective acid catalyst for the hydrogenation of imines and N-heterocycles

Palladium catalysts supported on acidic fluorinated magnesium hydroxide Pd/MgF2-x(OH)x were prepared through precipitation or impregnation methods. Applications to the hydrogenation of various aldimines and ketimines resulted in good catalytic activities at mild temperatures using one atmosphere of hydrogen. Quinolines, pyridines and other N-heterocycles were successfully hydrogenated at higher temperature and hydrogen pressure using low palladium loadings and without the use of any acid additive. Such reactivity trend confirmed the positive effect of the Br?nsted and Lewis acid sites from the fluorinated magnesium hydroxide support resulting in the effective pre-activation of N-heterocycle substrates and therefore in the good catalytic activity of the palladium nanoparticles during the hydrogenations. As demonstrated in the hydrogenation of imines, the catalyst was recycled up to 10 times without either loss of activity or palladium leaching. This journal is

Chan-Lam Amination of Secondary and Tertiary Benzylic Boronic Esters

We report a Chan-Lam coupling reaction of benzylic and allylic boronic esters with primary and secondary anilines to form valuable alkyl amine products. Both secondary and tertiary boronic esters can be used as coupling partners, with mono-alkylation of the aniline occurring selectively. This is a rare example of a transition-metal-mediated transformation of a tertiary alkylboron reagent. Initial investigation into the reaction mechanism suggests that transmetalation from B to Cu occurs through a single-electron, rather than a two-electron process.