33889-69-9

Basic information

• Product Name: Silicristin
• Synonyms: SILYCHRISTIN;SILYCRISTIN;SILICHRISTIN;Silicristin;SILYCHRISTIN hplc;4H-1-Benzopyran-4-one,2-[(2R, 3S)-2,3-dihydro-7-;hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranyl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-;Silychristin A
• CAS NO: 33889-69-9
• Molecular Formula: C₂₅H₂₂O₁₀
• Molecular Weight: 482.44
• EINECS: 251-720-9
• Product Categories: Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 33889-69-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 174～176℃
• Boiling Point: 782oC at 760 mmHg
• Flash Point: 270.5oC
• Appearance: /
• Density: 1.578g/cm3
• Vapor Pressure: 9.44E-26mmHg at 25°C
• Refractive Index: 1.716
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Methanol (Slightly)
• PKA: 7.39±0.60(Predicted)
• CAS DataBase Reference: Silicristin(CAS DataBase Reference)
• NIST Chemistry Reference: Silicristin(33889-69-9)
• EPA Substance Registry System: Silicristin(33889-69-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-45
• WGK Germany: 3
• Hazardous Substances Data: 33889-69-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 33889-69-9 differently. You can refer to the following data:
1. Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic fla vonolignan.
2. Silychristin is a new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. Silychristin has been shown to be an antihepatotoxic flavonolignan.

Definition

ChEBI: A flavonolignan isolated from Silybum marianum and has been shown to exhibit inhibitory activities against lipoxygenase and prostaglandin synthetase.

InChI:InChI=1/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1

Upstream product

• 16414-34-9 3-bromo-4,5-dihydroxybenzaldehyde 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 36804-11-2 2,4,6-tri-MOM phloracetophenone 
• 124662-50-6 3,4-Bis(benzyloxy)-5-brombenzaldehyd 
• 119384-64-4 3,4-dibenzyloxy-5-formylbenzaldehyde dimethyl acetal 
• 119384-63-3 5-bromo-3,4-benzyloxybenzaldehyde dimethyl acetal 
• 119384-70-2 (E)-3-[(2S,3R)-7-Methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-yl]-1-(2,4,6-tris-methoxymethoxy-phenyl)-propenone 
• 119384-65-5 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-dimethoxymethylphenyl)-2-propen-1-one 
• 119384-66-6 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-formylphenyl)-2,3-epoxy-1-propanone 
• 119389-99-0 1-(4-Benzyloxy-3-methoxy-phenyl)-2-(2,3-bis-benzyloxy-5-hydroxymethyl-phenyl)-propane-1,3-diol 
• 124662-51-7 1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-formylphenyl)-2-propen-1-one 
• 124662-57-3 Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester 
• 119390-00-0 (2S,3R)-7-Methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-carbaldehyde 
• 124662-58-4 [(2S,3R)-7-Methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-yl]-methanol 

Downstream Products

• 57499-41-9 2,3-dehydrosilychristin A 
• 55607-52-8 isohydnocarpin 

Relevant articles and documents

Total synthesis of silychristin, an antihepatotoxic flavonolignan

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