33955-17-8

Basic information

• Product Name: (THIOPHENE-2-CARBONYL)-AMINO]-ACETIC ACID
• Synonyms: N-[(Thien-2-yl)carbonyl]glycine;2-(thiophene-2-carbonylaMino)acetic Acid;((2-THIENYLCARBONYL)AMINO)ACETIC ACID
• CAS NO: 33955-17-8
• Molecular Formula: C₇H₇NO₃S
• Molecular Weight: 185.202
• Mol File: 33955-17-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 494.8 °C at 760 mmHg
• Flash Point: 253.1 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 1.31E-10mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (THIOPHENE-2-CARBONYL)-AMINO]-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (THIOPHENE-2-CARBONYL)-AMINO]-ACETIC ACID(33955-17-8)
• EPA Substance Registry System: (THIOPHENE-2-CARBONYL)-AMINO]-ACETIC ACID(33955-17-8)

Safety Data

• Hazardous Substances Data: 33955-17-8(Hazardous Substances Data)

Usage

General Description

The chemical compound (thiophene-2-carbonyl)-amino]-acetic acid, also known as 2-thiophenecarboxylic acid, is a derivative of thiophene containing an amino acid group. It is a white to light yellow crystalline powder with a molecular formula C7H7NO3S. (THIOPHENE-2-CARBONYL)-AMINO]-ACETIC ACID is often used as a building block in the synthesis of pharmaceuticals and other organic compounds due to its functional groups and reactivity. It can also serve as a precursor for the production of various derivatives and analogs with potential therapeutic applications. The (thiophene-2-carbonyl)-amino]-acetic acid is also of interest to researchers in the field of organic chemistry and drug design.

InChI:InChI=1/C7H7NO3S/c9-6(10)4-8-7(11)5-2-1-3-12-5/h1-3H,4H2,(H,8,11)(H,9,10)

Upstream product

• 527-72-0 2-thiophenylcarboxylic acid 
• 56-40-6 glycine 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 301164-69-2 (1H-benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone 

Downstream Products

• 230283-16-6 2-(2-thienyl)-oxazolone 
• 63203-31-6 methyl 2-(thiophene-2-carboxamido)acetate 
• 326026-75-9 C₂₄H₂₁N₅O₄S₃ 
• 1262755-86-1 C₃₁H₃₇N₃O₃S 
• 1160366-91-5 (S)-N-[[3-[3-fluoro-4-[4-[2-(thiophene-2-carboxamido)acetyl]piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 904664-93-3 4-(2-nitrobezylidene)-2-(2-thienyl)-4,5-dihydrooxazol-5-one 
• 527-72-0 2-thiophenylcarboxylic acid 
• 56-40-6 glycine 
• 72978-96-2 4-(E)-benzylidene-2-thiophen-2-yl-4H-oxazol-5-one 
• 72978-97-3 2-thiophen-2-yl-4-((E)-4-vinyl-benzylidene)-4H-oxazol-5-one 

Relevant articles and documents

4-Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae

A current issue of antimicrobial therapy is the resistance to treatment with worldwide consequences. Thus, the identification of innovative targets is an intriguing challenge in the drug and development process aimed at newer antimicrobial agents. The state-of-art of anticholera therapy might comprise the reduction of the expression of cholera toxin, which could be reached through the inhibition of carbonic anhydrases expressed in Vibrio cholerae (VchCAα, VchCAβ, and VchCAγ). Therefore, we focused our interest on the exploitation of sulfonamides as VchCA inhibitors. We planned to design and synthesize new benzenesulfonamides based on our knowledge of the VchCA catalytic site. The synthesized compounds were tested thus collecting useful SAR information. From our investigation, we identified new potent VchCA inhibitors, some of them displayed high affinity toward VchCAγ class, for which few inhibitors are currently reported in literature. The best interesting VchCAγ inhibitor (S)-N-(1-oxo-1-((4-sulfamoylbenzyl)amino)propan-2-yl)furan-2-carboxamide (40) resulted more active and selective inhibitor when compared with acetazolamide (AAZ) as well as previously reported VchCA inhibitors.

Synthesis, biological activity screening and molecular modeling study of acylaminoacetamide derivatives

In this study, non-rigid analogs of thalidomide have been designed in order to develop potentially active, more effective and safer lead molecules for disorders caused or contributed by inflammation. Five different series of acylaminoacetamide compounds were synthesized, and the biological inhibitory potency of the title compounds has been determined by evaluating their effects on COX-2 isoenzyme expression and PGE2 production in A549 (human lung adenocarcinoma) cell lines. Among the studied series, N-[2-(isopropylamino)-2-oxoethyl]isonicotinamide is the most active inhibitory compound on COX-2 isoenzyme expression, and N-[2-oxo-2-(pyrolydine-1-yl)etyl]isonicotinamide is the most active inhibitory compound on the biosynthesis of PGE2. Molecular docking studies and molecular dynamics simulations were also applied to investigate non-covalent interactions of the most active compounds inside the active side of the crystal structure of murine cyclooxygenase 2 (mCOX-2) isoenzyme.

PYRIMIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS

Pyrimidine derivatives are ubiquitination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders.