342-25-6Relevant articles and documents
Method of utilizing continuous flow microreactor to synthesize benzophenone derivative
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Paragraph 0049-0052, (2018/09/11)
The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.
A novel Br?nsted acid catalyst for Friedel-Crafts acylation
Posternak, Anna G.,Garlyauskayte, Romute Yu.,Yagupolskii, Lev M.
supporting information; body text, p. 446 - 447 (2009/05/27)
Bis(trifluoroalkylsulfonylimino)trifluoromethanesulfonic acid has demonstrated remarkable catalytic ability in the electrophilic acylation of aromatic substrates. Various perfluoroalkyl substituted aroyl chlorides are employed in Friedel-Crafts acylation typically using 1 mol % of catalyst. Crown Copyright
Influence of isomerism of difluorobenzophenone on the synthesis and properties of poly(arylene ether ketones)
Salazkin,Shaposhnikova,Donetskii,Gorshkov,Blagodatskikh,Dubrovina,Sakunts,Petrovskii,Komarova,Genina,Tkachenko,Askadskii,Bychko,Kazantseva
, p. 1208 - 1213 (2007/10/03)
The influence of isomerism of difluorobenzophenone on the efficiency of polycondensation and the properties of homo-and copoly(arylene ether ketones) was studied. The latter were prepared by the reaction of 2,4'-and 4,4'-difluorobenzophenone with potassium diphenolates of bisphenol A and phenolphthalein in N,N-dimethylacetamide. A high content of an admixture of the 2,4'-isomer in 4,4'-difluorobenzophenone decreases the molecular weight of related poly(arylene ether ketones) and has no substantial effect on their glass transition temperature.