344340-95-0Relevant articles and documents
Synthesis of isocoumarins and α-pyrones via iodocyclization
Yao, Tuanli,Larock, Richard C
, p. 7401 - 7404 (2002)
A variety of 3-substituted 4-iodoisocoumarins and 6-substituted 5-iodo-2(2H)-pyranones are readily prepared in excellent yields under mild reaction conditions by the reaction of o-(1-alkynyl)benzoates and (Z)-2-alken-4-ynoates with ICl.
Synthesis of isocoumarins and α-pyrones via electrophilic cyclization
Yao, Tuanli,Larock, Richard C.
, p. 5936 - 5942 (2007/10/03)
A variety of substituted isocoumarins and α-pyrones are readily prepared in excellent yields under very mild reaction conditions by the reaction of o-(1-alkynyl)benzoates and (Z)-2-alken-4-ynoates with ICl, I2, PhSeCl, p-O2NC6/
A novel route to 6-substituted and 5,6-disubstituted 2-pyrones
Bellina, Fabio,Biagetti, Matteo,Carpita, Adriano,Rossi, Renzo
, p. 2859 - 2863 (2007/10/03)
6-Alkyl- and 6-(1-alkenyl)-5-iodo-2-pyrones, which are available as major products by reaction of the corresponding (Z)-2-en-4-ynoic acids with iodine and NaHCO3 in CH3CN, undergo insertion of activated zinc metal into their carbon-iodine bond to provide the corresponding 5-(iodozinc)-2-pyrones. Hydrolysis of these organometallics gives 6-substituted 2-pyrones in satisfactory yields including two natural products. On the other hand, the Pd-catalyzed reaction of the organozincs either with an activated alkenyl halide or with activated and deactivated (hetero)aryl halides provides 5,6-disubstituted 2-pyrones in fair to good yields.
