3449-44-3

Basic information

• Product Name: diethyl 2,6-dihydroxy-4-phenyl-2,6-bis(trifluoromethyl)tetrahydro-2H-pyran-3,5-dicarboxylate
• Synonyms: Diethyl 2,6-dihydroxy-4-phenyl-2,6-bis(trifluoromethyl)tetrahydro-2H-pyran-3,5-dicarboxylate
• CAS NO: 3449-44-3
• Molecular Formula: C₁₉H₂₀F₆O₇
• Molecular Weight: 474.3483
• Mol File: 3449-44-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 475°C at 760 mmHg
• Flash Point: 241.1°C
• Density: 1.451g/cm³
• Vapor Pressure: 7.88E-10mmHg at 25°C
• Refractive Index: 1.479
• CAS DataBase Reference: diethyl 2,6-dihydroxy-4-phenyl-2,6-bis(trifluoromethyl)tetrahydro-2H-pyran-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2,6-dihydroxy-4-phenyl-2,6-bis(trifluoromethyl)tetrahydro-2H-pyran-3,5-dicarboxylate(3449-44-3)
• EPA Substance Registry System: diethyl 2,6-dihydroxy-4-phenyl-2,6-bis(trifluoromethyl)tetrahydro-2H-pyran-3,5-dicarboxylate(3449-44-3)

Safety Data

• Hazardous Substances Data: 3449-44-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Relevant articles and documents

Reactions of alkyl 2-benzylidene-2-polyfluoroacylacetates with N,N-dinucleophiles

Alkyl 2-benzylidene-2-polyfluoroacylacetates react with urea and thiourea to yield 5-ethoxycarbonyl-4-fluoroalkyl-4-hydroxy-6-phenylhexahydropyrimidin-2- ones and -2-thiones and with guanidine sulfate to form 2-amino-5-ethoxycarbonyl- 4-fluoroalkyl-6-phenyl-1,6-dihydropyrimidines and 3,6-diethoxycarbonyl-2,7- difluoroalkyl-4,5-diphenyl-4,5-dihydro-1H-pyrido[1,2-a]pyrimidines, and they react with phenylhydrazine to afford 4-alkoxycarbonyl-3-fluoroalkyl-3-hydroxy-1, 5-diphenylpyrazolidines. Hydrazine hydrate catalyzes the formation of 3,5-diethoxycarbonyl-2,6-difluoroalkyl-2,6-dihydroxy-4-phenyltetrahydropyrans. When treated with anhydrous hydrazine and o-phenylenediamine, these esters cleave to form the products of condensation of fluoroacyl ester and benzaldehyde with diamines.