372-31-6

Basic information

• Product Name: Ethyl 4,4,4-trifluoroacetoacetate
• Synonyms: ETHYL 3-OXO-4,4,4-TRIFLUOROACETOACETATE;ETHYL 3-OXO,4,4,4-TRIFLUOROBUTYRATE;ETHYL 4,4,4-TRIFLUOROACETOACETATE;ETHYL 4,4,4-TRIFLUOROACETOACTATE;ETHYL 4,4,4-TRIFLUORO-3-OXOBUTANOATE;ETHYL TRIFLUOROACETOACETATE;4,4,4-TRIFLUORO-3-OXOBUTANOIC ACID ETHYL ESTER;4,4,4-TRIFLUOROACETOACETIC ACID ETHYL ESTER
• CAS NO: 372-31-6
• Molecular Formula: C₆H₇F₃O₃
• Molecular Weight: 184.11
• EINECS: 206-750-7
• Product Categories: Pharmaceutical Intermediates;Aliphatics;Esters;Organic Fluorides;Fluorochemicals;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry
• Mol File: 372-31-6.mol
• Article Data: 24

Chemical Properties

• Melting Point: -39 °C
• Boiling Point: 129-130 °C(lit.)
• Flash Point: 84 °F
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 1.259 g/mL at 25 °C(lit.)
• Vapor Pressure: 8hPa at 20℃
• Refractive Index: n20/D 1.375(lit.)
• Storage Temp.: Flammables area
• Solubility: 10g/l
• PKA: 7.76±0.10(Predicted)
• Water Solubility: 10 g/L (20 ºC)
• BRN: 608353
• CAS DataBase Reference: Ethyl 4,4,4-trifluoroacetoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)
• EPA Substance Registry System: Ethyl 4,4,4-trifluoroacetoacetate(372-31-6)

Safety Data

• Hazard Codes: Xn,F,C,Xi
• Statements: 10-22-52/53
• Safety Statements: 61-16
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 2
• TSCA: T
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 372-31-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear liquid

Uses

Different sources of media describe the Uses of 372-31-6 differently. You can refer to the following data:
1. Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet
2. Widely used in the synthetic process of medicine, pesticides and organic intermediate.
3. Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Flammability and Explosibility

Flammable

InChI:InChI=1/C6H7F3O3/c1-2-12-5(11)3-4(10)6(7,8)9/h2-3H2,1H3

Synthetic route

ethyl trifluoroacetate, (383-63-1) + ethyl acetate (141-78-6) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With sodium hydride In diethyl ether; paraffin reflux, 2 h and r.t., 12 h;	85%
Stage #1: ethyl acetate With sodium ethanolate at 0 - 5℃; for 1h; Stage #2: ethyl trifluoroacetate, at 0 - 65℃; for 25h;	70.7%
With diethyl ether; sodium ethanolate

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + trimethylsilyl trifluoroacetate (400-53-3) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium In tetrahydrofuran Stage #2: trimethylsilyl trifluoroacetate In tetrahydrofuran Stage #3: With hydrogenchloride In tetrahydrofuran Further stages.;	55%
With n-butyllithium 1.) THF, -78 deg C, 20 min, 2.) THF, RT, 5 h; Yield given. Multistep reaction;

ethyl 2-fluoroacetate (459-72-3) + ethyl difluoroacetate (454-31-9) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With sodium hydride

Trifluoracetyl-glyoxylsaeure-aethylester-α-hydrazon (652-71-1) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With quinoline In ethanol

3-acetoxy-4,4,4-trifluoro-but-2-enoic acid ethyl ester (2707-65-5) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With sodium tetrahydroborate In ethanol

ethyl trifluoroacetate, (383-63-1) + ethyl acetate (141-78-6) → Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat (197850-97-8) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With ethanol; sulfuric acid; sodium at 90℃; for 48h; Heating;
With sodium ethanolate In ethanol for 48h; Heating;

3-tert-Butylperoxy-4,4,4-trifluoro-3-hydroxy-butyric acid ethyl ester (129657-54-1) → tert.-butylhydroperoxide (75-91-2) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
In tetrachloromethane at 20℃; Equilibrium constant; Rate constant;

ethanol (64-17-5) + 2,2-Dimethyl-5-(2,2,2-trifluoro-1-hydroxy-ethylidene)-[1,3]dioxane-4,6-dione (693817-83-3) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
at 70℃; for 6h; Ring cleavage; Decarboxylation;

ethyl acetate (141-78-6) + sodium compound of orthotrifluoroacetic acid diethyl ester → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

diethyl ether (60-29-7) + ethyl trifluoroacetate, (383-63-1) + sodium → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat (197850-97-8) → ethyl 3-trifluoromethyl-3-oxo-propionate (106260-08-6) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
In tetrahydrofuran-d8 Equilibrium constant;

ethyl 3-trifluoromethyl-3-oxo-propionate (106260-08-6) → Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat (197850-97-8) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With water In tetrahydrofuran-d8 Equilibrium constant;

diazoacetic acid ethyl ester (623-73-4) + Trifluoroacetaldehyde ethyl hemiacetal (433-27-2) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
Stage #1: ethyl trifluoroacetaldehyde hemiacetal With sulfuric acid at 70 - 150℃; for 0.133333h; microwave irradiation; Stage #2: diazoacetic acid ethyl ester In dichloromethane at 20℃; for 0.25h; Further stages.;	15 % Chromat.

ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate (18955-75-4) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: diisopropyl ether 2: H2O; methanol / Heating 3: quinoline / ethanol View Scheme

Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-(2) (2559-41-3) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O; methanol / Heating 2: quinoline / ethanol View Scheme

sodium 4-ethoxy-1,1,1-trifluoro-4-oxobut-2-en-2-olate (22466-45-1) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With hydrogenchloride In water at 5 - 10℃; for 3h; pH=1 - 3;

1,1,1-trifluoro-2-propanone (421-50-1) + Diethyl carbonate (105-58-8) → ethyl 4,4,4-trifluoroacetoacetate (372-31-6)

Conditions	Yield
With sodium hydride In toluene Inert atmosphere; Reflux;

biguanide sulfate (2583-53-1, 6945-23-9, 49719-55-3) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → N-(4-hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-guanidine

Conditions	Yield
Stage #1: biguanide sulfate With sodium hydroxide In ethanol at 0 - 20℃; Stage #2: ethyl 4,4,4-trifluoroacetoacetate In ethanol for 2.5h; Heating; Further stages.;	100%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + benzyl alcohol (100-51-6) → benzyl 4,4,4-trifluoroacetoacetate (83097-87-4)

Conditions	Yield
In toluene at 120℃; for 5h; Dean-Stark;	100%
In toluene Heating;

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + 4-(2-hydroxy-benzylidene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one (68761-48-8) → 5-ethoxylcarbonyl-6-hydroxy-4-(2-hydroxyphenyl)-1-phenyl-3-methyl-6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran

Conditions	Yield
With ammonium acetate In ethanol at 20℃; for 2h;	100%

aluminum ethoxide (555-75-9) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + acetylacetone (123-54-6) → monoacetylacetonate aluminum bis(ethyl-4,4,4-trifluoroacetoacetate)

Conditions	Yield
In toluene at 20℃; for 24h;	100%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate (363-58-6)

Conditions	Yield
With sulfuryl dichloride In dichloromethane at -5 - 20℃;	99.3%
With chlorine In acetone	95%
With chlorine at 0 - 30℃; Cooling with acetone-dry ice;	95%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + recorcinol (108-46-3) → 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one (575-03-1)

Conditions	Yield
With iodine In toluene at 80℃; Pechmann reaction;	99%
With magnesium bis(trifluoromethane solfonyl)imide In neat (no solvent) at 80℃; for 0.416667h; Pechmann Condensation;	97%
indium(III) chloride at 65℃; for 0.5h; von Pechmann reaction;	96%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 3-hydroxy-4,4,4-trifluorobutyrate (372-30-5)

Conditions	Yield
With formic acid; C18H24ClIrN3 In water at 80℃; for 8h; Schlenk technique; Inert atmosphere; chemoselective reaction;	99%
With sodium tetrahydroborate In diethyl ether 1.) 0-5 deg C, 1 h, 2.) r.t., overnight;	98%
With sodium tetrahydroborate In diethyl ether	97%

7-ethyl-1H-indole (22867-74-9) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 3-(7-ethyl-1H-indol-3-yl)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions	Yield
With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate In dichloromethane at 20℃; for 76h; Friedel-Crafts reaction; optical yield given as %ee; enantioselective reaction;	99%

4-chlorobenzylamine (104-86-9) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate (1384849-55-1)

Conditions	Yield
Stage #1: 4-chlorobenzylamine With acetic acid In chloroform at 20℃; for 0.0833333h; Stage #2: ethyl 4,4,4-trifluoroacetoacetate In chloroform for 5h; Reflux;	99%

6-methylbenzothiazol-2-ylamine (2536-91-6) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 8-methyl-2-(trifluoromethyl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

Conditions	Yield
With indium(III) triflate In toluene at 100℃; for 16h; regioselective reaction;	99%

4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7, 27918-19-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (627094-59-1)

Conditions	Yield
In ethanol at 24℃; Reflux; Inert atmosphere;	99%

1,3-cylohexanedione (504-02-9) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions	Yield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Pechmann Condensation; Glovebox; Inert atmosphere;	99%

5-methylcyclohexan-1,3-dione (4341-24-6) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 7-methyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions	Yield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;	99%

dimedone (126-81-8) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 7,7-dimethyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions	Yield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;	99%

5-phenyl-cyclohexane-1,3-dione (493-72-1) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 7-phenyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions	Yield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;	99%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + 4-aminosulfonylphenylhydrazine (4392-54-5) → 4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (627094-59-1)

Conditions	Yield
In ethanol for 12h; Reflux;	99%

orthoformic acid triethyl ester (122-51-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate (571-55-1)

Conditions	Yield
With acetic anhydride at 120 - 140℃; for 7h; Condensation;	98%
With acetic anhydride at 135℃; for 18h;	97.1%
In acetic anhydride for 8h; Reflux;	95%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 5-(trifluoromethyl)-4-pyrazolin-3-one (76480-99-4)

Conditions	Yield
With hydrazine hydrate In ethanol; water for 18h; Heating;	98%
With water; hydrazine hydrate
With ethanol; hydrazine hydrate

5-amino-1,2-dihydropyrazol-3-one (28491-52-3) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 4-trifluoromethyl-6-hydroxy-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine

Conditions	Yield
With acetic acid for 2h; Heating;	98%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + m-Hydroxyaniline (591-27-5) → Coumarin 151 (53518-15-3)

Conditions	Yield
With magnesium bis(trifluoromethane solfonyl)imide In neat (no solvent) at 80℃; for 0.416667h; Pechmann Condensation;	98%
With sulfuric acid In ethanol at 80℃;	83%
With zinc(II) chloride In ethanol for 12h; Heating;	69%
With zinc(II) chloride In ethanol Reflux;	12%
With zinc(II) chloride In ethanol for 12h; Reflux;

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 3-amino-4,4,4-trifluorocrotonate (141860-78-8)

Conditions	Yield
With ammonium acetate In cyclohexane; isopropyl alcohol	98%
With ammonium acetate In ethanol; water	88%
With ammonia

2,3;4,5-di-O-isopropylidene-β-D-fructopyranose (20880-92-6) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 4,4,4-Trifluoro-3-oxo-butyric acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester

Conditions	Yield
With vermiculite In toluene for 48h; Heating;	98%

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (4099-85-8) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 4,4,4-Trifluoro-3-oxo-butyric acid (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Conditions	Yield
With vermiculite In toluene for 48h; Heating;	98%

indole (120-72-9) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 3-hydroxy-3-(indol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions	Yield
With K-10 montmorillonite In toluene at 70℃; for 1h; Friedel-Crafts hydroxyalkylation;	98%

2-methyl-1H-indole (95-20-5) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 3-hydroxy-3-(2-methylindol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions	Yield
With K-10 montmorillonite In toluene at 70℃; for 0.75h; Friedel-Crafts hydroxyalkylation;	98%

pyrrole (109-97-7) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 3-hydroxy-3-(pyrrol-2-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions	Yield
With K-10 montmorillonite In toluene at 70℃; for 0.5h; Friedel-Crafts hydroxyalkylation;	98%

phenylhydrazine (100-63-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one (321-07-3)

Conditions	Yield
at 150 - 160℃; for 3h;	98%
With acetic acid for 6h; Reflux;	90%
With acetic acid Reflux;	90%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate (85571-85-3)

Conditions	Yield
With α-D-glucose 6-phosphate; permeabilized cells of Bacillus pumilus Phe-C3; NADPH In various solvent(s) at 25℃; for 24h; pH=7.0;	98%
With glucose dehydrogenase; pET28-bmgdh-cgcr; sodium carbonate In aq. phosphate buffer; toluene at 30℃; for 12h; pH=6.5; Enzymatic reaction; enantioselective reaction;	92%
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In dimethyl sulfoxide at 30℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	66%

phenylhydrazine (100-63-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (96145-98-1)

Conditions	Yield
With acetic acid at 10 - 80℃; for 6.5h;	98%
In ethanol at 24℃; for 12h; Reflux; Inert atmosphere;	92%
In ethanol for 12h; Reflux;	92%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + methylamine (74-89-5) → 3-methylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester (507448-65-9)

Conditions	Yield
With acetic acid In ethanol; methyl cyclohexane at 80 - 90℃; under 760.051 Torr; for 3 - 4h; Product distribution / selectivity;	98%
With acetic acid In methyl cyclohexane at 80 - 85℃; for 3 - 8h; Product distribution / selectivity;	88.5%

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 141-78-6 ethyl acetate 
• 60-29-7 diethyl ether 
• 652-71-1 Trifluoracetyl-glyoxylsaeure-aethylester-α-hydrazon 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 541-41-3 chloroformic acid ethyl ester 
• 64-18-6 formic acid 
• 22466-45-1 sodium 4-ethoxy-1,1,1-trifluoro-4-oxobut-2-en-2-olate 
• 105-58-8 Diethyl carbonate 
• 2559-41-3 Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-⁽²⁾ 
• 18955-75-4 ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate 
• 623-73-4 diazoacetic acid ethyl ester 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 106260-08-6 ethyl 3-trifluoromethyl-3-oxo-propionate 

Downstream Products

• 368-54-7 2-sulfanylidene-6-(trifluoromethyl)-2,3-dihydropyrimidin-4(1H)-one 
• 782-55-8 2-(trifluoroacetonyl)benzimidazole 
• 3449-43-2 2,6-Dihydroxy-2,6-bis-trifluormethyl-4-<4-fluor-phenyl>-tetrahydropyran-dicarbonsaeure-(3,5)-diethylester 
• 121671-61-2 dibenzyl-2,2 trifluoroacetylacetate d'ethyle 
• 118642-72-1 benzyl-2 trifluoroacetylacetate d'ethyle 
• 135787-54-1 ethyl 4-oxo-2-(trifluoromethyl)-2-cyclohexene-1-carboxylate 
• 135787-53-0 4-carboethoxy-3-hydroxy-3-trifluoromethylcyclohexanone 
• 53518-16-4 4-trifluoromethyl-6,7,8,9-tetrahydro-pyrano[3,2-g]quinolin-2-one 
• 24915-95-5 Ethyl (R)-3-hydroxybutanoate 
• 372-30-5 ethyl (3S)-4,4,4-trifluoro-3-hydroxybutanoate 
• 85571-85-3 ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate 
• 141-97-9 ethyl acetoacetate 
• 852613-17-3 4,4,4-trifluoro-3-oxo-butyric acid 4-nitro-benzyl ester 
• 83097-87-4 benzyl 4,4,4-trifluoroacetoacetate 

Relevant articles and documents

-

-

Preparation method of sodium formate

The invention discloses a preparation method of sodium formate. The method adopts trifluoroacetoacetic acid ethyl enol sodium salt and formic acid as raw materials, and comprises the following steps: A1, adding formic acid into an ethyl trifluoroacetoacetate enol sodium salt solution, controlling the temperature at 10-60 DEG C, and carrying out heat preservation reaction for 2.0-5.0 hours after the formic acid is added; and A2, carrying out solid-liquid separation on the reaction liquid, wherein the separated solid is crude sodium formate. The method has the advantages of mild reaction, high safety, high sodium formate purity, basically no three wastes and the like.

Production technology of ethyl trifluoroacetoacetate

Ethyl trifluoroacetoacetate is an important chemical engineering raw material. The process flow of a production technology of ethyl trifluoroacetoacetate comprises the following steps: 1, a condensation reaction; 2, first-stage distillation; 3, neutralization; 4, suction filtration; 5, rectification; 6, esterification recovery; and 7, second-stage distillation.