345-90-4

Basic information

• Product Name: 1,1'-(bromomethylene)bis(4-fluorobenzene)
• Synonyms: Benzene,1,1'-(bromomethylene)bis[4-fluoro-;1,1'-(bromomethylene)bis(4-fluorobenzene);4,4'-DIFLUORO-DIPHENYL-BROMOMETHANE;Bis-(4-fluorophenyl)bromomethane;1-[bromo-(4-fluorophenyl)methyl]-4-fluorobenzene;1-[bromo-(4-fluorophenyl)methyl]-4-fluoro-benzene;bromobis(4-fluorophenyl)methane
• CAS NO: 345-90-4
• Molecular Formula: C₁₃H₉BrF₂
• Molecular Weight: 283.1113664
• EINECS: 206-465-8
• Mol File: 345-90-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 302.4±32.0 °C(Predicted)
• Appearance: /
• Density: 1.480±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: 1,1'-(bromomethylene)bis(4-fluorobenzene)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-(bromomethylene)bis(4-fluorobenzene)(345-90-4)
• EPA Substance Registry System: 1,1'-(bromomethylene)bis(4-fluorobenzene)(345-90-4)

Safety Data

• Hazardous Substances Data: 345-90-4(Hazardous Substances Data)

Usage

Uses

4,4''-Difluorobenzhydryl Bromide can be prepared as MAGL inhibitors

Upstream product

• 365-24-2 4,4'-difluorobenzhydryl alcohol 
• 459-57-4 4-fluorobenzaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 345-92-6 4,4'-Difluorobenzophenone 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 435-08-5 1,1,2,2-tetrakis(4-fluoroophenyl)ethylene 
• 141528-78-1 1-nitroso-4-[(4',4''-difluorodiphenyl)methyl]piperazine 
• 170366-91-3 2,2,2-trifluoro-1-[1-di(4-fluorophenyl)methylindol-5-yl]-1-ethanone 
• 915134-70-2 2-acetylamino-3,3-bis(4-fluorophenyl)propanoic acid 
• 53915-75-6 1-[bis(4-fluorophenyl)methoxy]-2-bromoethane 
• 129084-52-2 1-[bis(4-fluorophenyl)methoxy]-3-bromopropane 
• 205389-52-2 [(2-Bis(4-fluorophenyl)methylthio-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic Acid 
• 205389-70-4 [(2-Bis(4-fluorophenyl)methylsulfonyl-4,5-dihydronaphtho[1,2-d]thiazol-6-yl)oxy]acetic Acid 
• 1218941-17-3 C₂₉H₂₈ClF₂N₃O 
• 1235479-38-5 C₂₂H₁₈F₂O 
• 1259025-04-1 1-(4-chlorophenyl)-2,2-bis(4-fluorophenyl)ethanone 
• 918625-32-8 4-fluoro-β-(4-fluorophenyl)-L-phenylalanine hydrochloride 

Relevant articles and documents

MAGL inhibitor as well as preparation method and application thereof

The invention relates to a compound shown as a formula I in the description and a pharmaceutically acceptable salt thereof, a preparation method, an intermediate for preparing the compound, a composition containing the compound or salt, and application of the compound for preparing drugs for treating MAGL-mediated diseases and symptoms.

Light-Induced Alkylation of (Hetero)aromatic Nitriles in a Transition-Metal-Free C-C-Bond Metathesis

A light-induced C-C-σ-bond metathesis was achieved through transition-metal-free activation of an unstrained C(sp3)-C(sp3)-σ-bond in 1-benzyl-1,2,3,4-tetrahydroisoquinolines. A photoredox-mediated single-electron oxidation of these precursor amines yield radical cations which undergo a homolytic cleavage of a C(sp3)-C(sp3)-σ-bond rather than the well-known α-C-H-scission. The resulting carbon-centered radicals are used in the ipso-substitution of (hetero)aromatic nitriles proceeding through another single-electron transfer-mediated C-C-bond cleavage and formation.

Synthesis and anticonvulsant activity of some cinnamylpiperazine derivatives

A series of cinnamylpiperazine derivatives was synthesized using different benzophenone as starting material. The structures of the compounds were proved by their IR, 1H-NMR spectroscopic data and mass spectra data. The anticonvulsant activities of these compounds were evaluated with maximal electroshock (MES) test and rotarod test with intraperitoneal injection on KunMing mice. Among all the flunarizine analogues, no one exhibited better anticonvulsant activity than flunarizine. Flunarizine (4i) exhibited anticonvulsant activity with ED50 of 38.1 mg/kg, TD50 of 164.3 mg/kg and PI of 4.3 through administration intraperitoneal, and with ED50 of 56.8 mg/kg, TD50 of 456.3 mg/kg and PI of 8.0 through oral administration.