347-91-1

Basic information

• Product Name: 2-(4-FLUOROPHENYL)ACETOPHENONE
• Synonyms: 2-(4-FLUOROPHENYL)-1-PHENYL ETHANONE;Ethanone, 2-(4-fluorophenyl)-1-phenyl-
• CAS NO: 347-91-1
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.24
• Mol File: 347-91-1.mol
• Article Data: 47

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 325.9°Cat760mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000224mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)ACETOPHENONE(347-91-1)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)ACETOPHENONE(347-91-1)

Safety Data

• Hazardous Substances Data: 347-91-1(Hazardous Substances Data)

Usage

General Description

2-(4-FLUOROPHENYL)ACETOPHENONE, also known as fluoroacetophenone, is a chemical compound with the molecular formula C14H11FO. It is a substituted acetophenone derivative that contains a functional group of a fluorine atom attached to the phenyl ring. 2-(4-FLUOROPHENYL)ACETOPHENONE is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It also has potential applications in organic synthesis and as a building block in the production of various fine chemicals. The presence of the fluorine atom makes 2-(4-FLUOROPHENYL)ACETOPHENONE a useful reagent for various transformations in organic chemistry, and it is frequently used as a starting material in the production of new compounds with specific properties. Overall, 2-(4-FLUOROPHENYL)ACETOPHENONE is a versatile chemical with important applications in various industries.

InChI:InChI=1/C14H11FO/c15-13-8-6-11(7-9-13)10-14(16)12-4-2-1-3-5-12/h1-9H,10H2

Upstream product

• 98-88-4 benzoyl chloride 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 532-27-4 1-chloroacetophenone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 71-43-2 benzene 
• 405-50-5 p-Fluorophenylacetic acid 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 395-21-1 1-(4-fluorophenyl)-1-phenylethylene 
• 352-13-6 4-flourophenylmagnesium bromide 
• 459-46-1 4-Fluorobenzyl bromide 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 352-33-0 1-Chloro-4-fluorobenzene 

Downstream Products

• 73424-44-9 2-(4-Fluorphenyl)-1-phenyl-1-ethanon-p-tolylsulfonylhydrazon 
• 23075-72-1 Benzoyl-p-fluor-phenyl-diazomethan 
• 31464-79-6 2-(4-Fluoro-phenyl)-2-{[1-(4-fluoro-phenyl)-2-oxo-2-phenyl-eth-(E)-ylidene]-hydrazono}-1-phenyl-ethanone 
• 855231-02-6 4-(4-fluoro-phenyl)-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 949524-35-0 (E)-3-chloro-2-(4-fluoro-phenyl)-3-phenylacrylaldehyde 
• 855231-04-8 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 855231-06-0 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 
• 1027039-32-2 C₂₁H₁₇ClFNO₂ 
• 855249-00-2 4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide 
• 855249-01-3 4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide 
• 855249-03-5 (6-{2-[3-(4-fluorophenyl)-1-isopropyl-5-(4-methoxybenzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester 
• 855249-04-6 (3R,5R)-7-[3-(4-fluoro-phenyl)-1-isopropyl-5-(4-methoxy-benzylcarbamoyl)-4-phenyl-1H-pyrrol-2-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester 
• 133235-88-8 2-(4-fluoro-phenyl)-1-phenyl-ethylamine 
• 146364-50-3 (2,2-Diethoxy-ethyl)-[2-(4-fluoro-phenyl)-1-phenyl-ethyl]-amine 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi3complex with a macrocyclic tris(salen)-ligand

A hetero-tetranuclear CeNi3 complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce-O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.

Preparation method of aryl ketone

The invention discloses a preparation method of aryl ketone. The preparation method comprises the following steps: mixing a phenyl epoxy compound, aryl trifluoromethanesulfonate, a phosphine ligand, a nickel source, alkali and an organic solvent, and conducting reacting in one step under the protection of inert gas to generate aryl ketone. The preparation method disclosed by the invention is simple in process, mild in conditions and low in cost, and paves a way for large-scale industrial production application, such as drug synthesis or natural product synthesis application, of aryl ketone serving as an important organic reaction intermediate.