347-93-3

Basic information

• Product Name: 3-CHLORO-4'-FLUOROPROPIOPHENONE
• Synonyms: 1-(4-Fluorophenyl)-3-chloro-1-propanone;4'-Fluoro-β-chloropropiophenone;3-Chloro-1-(4-fluorophenyl)-1-propanone;3-Chloro-4'-fluoropropiophenone,98%;3-Chloro-4'-fluoropropiophen;2-Chloro-4'-fluoropropiophenone;P-FLUORO-BETA-CHLOROPROPIOPHENONE;AKOS BBS-00006444
• CAS NO: 347-93-3
• Molecular Formula: C₉H₈ClFO
• Molecular Weight: 186.61
• EINECS: 206-475-2
• Product Categories: Ketones;Acetophenone Series;Aromatic Propiophenones (substituted);C9;Carbonyl Compounds
• Mol File: 347-93-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 47-49 °C(lit.)
• Boiling Point: 100-103°C 3mm
• Flash Point: 198 °F
• Appearance: light brown to orange-brown crystalline powder
• Density: 1.2298 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 1866785
• CAS DataBase Reference: 3-CHLORO-4'-FLUOROPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4'-FLUOROPROPIOPHENONE(347-93-3)
• EPA Substance Registry System: 3-CHLORO-4'-FLUOROPROPIOPHENONE(347-93-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-52/53-22
• Safety Statements: 37/39-26-61
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 347-93-3(Hazardous Substances Data)

Usage

Chemical Properties

LIGHT BROWN TO ORANGE-BROWN CRYSTALLINE POWDER

Upstream product

• 462-06-6 fluorobenzene 
• 625-36-5 2-chloropropionyl chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 700-84-5 5-fluoro-1-indanone 
• 132428-02-5 1-(4-Fluorophenyl)-3-([N-[4-(2,2,2-trifluoro-1-hydroxy)-1-(trifluoromethyl)ethyl]phenyl]amino)-1-propanone 
• 143667-27-0 1-(4-Fluoro-phenyl)-3-heptylamino-propan-1-one 
• 143667-22-5 3-Decylamino-1-(4-fluoro-phenyl)-propan-1-one 
• 1481-32-9 6-fluoroindan-1-one 
• 31736-75-1 3-chloro-1-(4-fluorophenyl)propan-1-ol 
• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 
• 200004-39-3 (R)-3-chloro-1-(4-fluorophenyl)propan-1-ol 
• 200004-40-6 (S)-3-chloro-1-(4-fluorophenyl)propan-1-ol 
• 37155-07-0 1-(4-Fluoro-phenyl)-3-p-tolylamino-propan-1-one 
• 143667-17-8 3-(Cyclohexylmethyl-amino)-1-(4-fluoro-phenyl)-propan-1-one 
• 143667-21-4 1-(4-Fluoro-phenyl)-3-octadecylamino-propan-1-one 
• 37155-08-1 1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one 

Relevant articles and documents

I2-Promoted Intramolecular Oxidative Cyclization of Butenyl Anilines: A Facile Route to Benzo[b]azepines

A metal-free approach for the synthesis of seven-membered N-heterocycles has been developed by the I2-promoted intramolecular cross-coupling/annulation of butenyl anilines. This cyclization reaction involves C?H activation and C?C bond formation and exhibits good functional group tolerance. A series of benzo[b]azepine derivatives are obtained in moderate to good yields.

Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress

Excess lipid accumulation can initiate the development and progression of atherosclerotic lesions, thus eventually leading to cardiovascular disease. Lipid-lowering medication therapy is one of the cornerstones of cardiovascular disease therapy. On the basis of the cholesterol absorption inhibitor ezetimibe, we successfully synthesized seven 2-azetidinone derivatives and eighteen 1H-pyrrole-2,5-dione derivatives. Most of the new compounds significantly inhibited cholesterol uptake in vitro. In addition, one of the most active inhibitors, 3-(4-fluorophenyl)-1-[(3S)-3-hydroxy-3-(4-hydroxyphenyl)propyl]-4-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione (14q), showed no cytotoxicity in L02 and HEK293T cell lines. Further evaluation indicated that 14q inhibited considerably the amount of TNF-α, ROS, MDA, and LDH in vitro. Therefore, 14q might be a novel cholesterol absorption inhibitor.

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.