34847-16-0

Basic information

• Product Name: 6-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde
• CAS NO: 34847-16-0
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.227
• Mol File: 34847-16-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 339.9°C at 760 mmHg
• Flash Point: 161.1°C
• Density: 1.166g/cm³
• Vapor Pressure: 8.9E-05mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 6-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde(34847-16-0)
• EPA Substance Registry System: 6-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde(34847-16-0)

Safety Data

• Hazardous Substances Data: 34847-16-0(Hazardous Substances Data)

Upstream product

• 91-62-3 6-methylquinoline 
• 64-18-6 formic acid 

Downstream Products

• 93817-07-3 1-benzoyl-6-methyl-1,2,3,4-tetrahydro-quinoline 
• 91-61-2 6-methyl-1,2,3,4 tetrahydroquinoline 

Relevant articles and documents

Recyclable Silica-Supported Iridium Catalysts for Selective Reductive Transformation of Quinolines with Formic Acid in Water

Mesoporous silica (SBA-15)-supported iridium catalysts are prepared by grafting of the newly developed cyclometalated iridium 2-aryl benzoxazole complexes with 3-(triethoxysilyl)-propyl-isocyanate (TEPIC) as a linker. The supported catalysts are characterized by solid-state NMR spectroscopy, small-angle X-ray scattering (SAXS), nitrogen physisorption, FTIR spectroscopy, and electron microscopy analysis, which indicate that the coordination environment of the iridium center as well as the two-dimensional hexagonal pore structure of SBA-15 is maintained after the immobilization. These supported catalysts have been successfully applied to the selective transfer hydrogenation of quinoline derivatives to 1,2,3,4-tetrahydroquinolines (THQs) with formic acid in pure water. Moreover, by simply adapting the amount of formic acid used, N-formyltetrahydroquinolines (FTHQs) could be selectively synthesized from quinolines in two-step, one-pot transfer hydrogenation/N-formylation reactions with these supported catalysts. Notably, these supported catalysts showed better catalytic reactivity than their homogeneous analogs, and they can be easily reused 12 times in the transformation of quinoline to N-formyltetrahydroquinoline (FTHQ) without significant loss of activity.

Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators

The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2, R3, A, B, D, m, n, x, and y are defined as described in the specification. The invention additionally provides a pharmaceutically composition comprising the compound of formula I, together with a method of using the same to treat or prevent neurological and psychiatric disorders. The compounds are useful in therapy related to the treatment or prevention of mGluR2 receptor-mediated disorders.