349-00-8

Basic information

• Product Name: N-(trifluoroacetyl)valine
• CAS NO: 349-00-8
• Molecular Formula: C₇H₁₀F₃NO₃
• Molecular Weight: 213.1544
• Mol File: 349-00-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 301.8°C at 760 mmHg
• Flash Point: 136.3°C
• Density: 1.317g/cm³
• Vapor Pressure: 0.00024mmHg at 25°C
• Refractive Index: 1.409
• CAS DataBase Reference: N-(trifluoroacetyl)valine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(trifluoroacetyl)valine(349-00-8)
• EPA Substance Registry System: N-(trifluoroacetyl)valine(349-00-8)

Safety Data

• Hazardous Substances Data: 349-00-8(Hazardous Substances Data)

Usage

General Description

N-(trifluoroacetyl)valine is a synthetic chemical compound with the molecular formula C7H10F3NO3. It is a derivative of valine, an essential amino acid that plays a crucial role in protein synthesis and muscle growth. The trifluoroacetyl group is a strong electron-withdrawing group, which can enhance the acidity, reactivity, and physicochemical properties of the compound. N-(trifluoroacetyl)valine is commonly used in organic synthesis, pharmaceutical research, and as a building block for the preparation of peptide-based drugs and biologically active molecules. It is also utilized in the field of medicinal chemistry for the development of new drugs with improved pharmacokinetic and pharmacodynamic properties. Additionally, it serves as a useful tool for studying the structure-activity relationships of various bioactive compounds.

Upstream product

• 354-32-5 trifluoracetyl chloride 
• 72-18-4 L-valine 
• 71-23-8 propan-1-ol 
• 17498-50-9 L-valine hydrochloride 
• 407-25-0 trifluoroacetic anhydride 
• 848860-95-7 S-dodecyl trifluorothioacetate 
• 76-05-1 trifluoroacetic acid 
• 758-42-9 1,1,1-trichloro-3,3,3-trifluoro-propan-2-one 
• 383-63-1 ethyl trifluoroacetate, 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 500-73-2 phenyl trifluoroacetate 

Downstream Products

• 2996-11-4 N-trifluoroacetyl-L-valine-(N'-trityl-hydrazide) 
• 404-30-8 N-trifluoroacetyl-L-valine anilide 
• 62227-09-2 methyl N--L-prolinate 
• 62227-10-5 methyl N--L-prolinate 
• 1115-74-8 Val-Ala 
• 639-49-6 N-(1-trifluoroacetyl-L-prolyl)-L-valine-(N'-trityl-hydrazide) 
• 4817-67-8 N-trifluoroacetyl-L-valinyl-L-phenylalanine methyl ester 
• 72-18-4 L-valine 
• 72636-02-3 Val-Thr 
• 3918-94-3 Val-Val 
• 97589-53-2 (S)-2,2,2-triuoro-N-(3-methyl-1-oxo-1-phenylbutan-2-yl)acetamide 
• 13211-31-9 tert-butyl L-valinate 
• 52558-81-3 N-(trifluoroacetyl)valine trimethylsilyl ester 

Relevant articles and documents

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The: Ortho -substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines

2,4-Bis(trifluoromethyl)phenylboronic acid is a highly effective catalyst for dehydrative amidation between carboxylic acids and amines. Mechanistic studies suggest that a 2:2 mixed anhydride is expected to be the only active species, and the ortho-substituent of boronic acid plays a key role in preventing the coordination of amines to the boron atom of the active species, thus accelerating the amidation. This catalyst works for α-dipeptide synthesis.

Synthesis of dipeptides based on valine and threonine

Val-Val, Val-Thr, and Thr-Val dipeptides were synthesized using trifluoroacetyl protecting group. The optical rotations of the products were similar to those of samples synthesized using Boc protection, which indicated the absence of racemization in the course of introduction and removal of trifluoroacetyl protection. Pleiades Publishing, Ltd., 2012.