3492-43-1

Basic information

• Product Name: [2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate
• Synonyms: [2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate
• CAS NO: 3492-43-1
• Molecular Formula: C9H14Br2O4
• Molecular Weight: 0
• Mol File: 3492-43-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 368.6°Cat760mmHg
• Flash Point: 176.8°C
• Appearance: /
• Density: 1.643g/cm³
• Vapor Pressure: 1.25E-05mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: [2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate(3492-43-1)
• EPA Substance Registry System: [2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate(3492-43-1)

Safety Data

• Hazardous Substances Data: 3492-43-1(Hazardous Substances Data)

Usage

General Description

[2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate is a chemical compound with the molecular formula C8H12Br2O4. It is a combined ester of acetyloxymethyl and acetate, containing bromomethyl and bromine atoms. [2-(acetyloxymethyl)-3-bromo-2-(bromomethyl)propyl] acetate is used in various chemical reactions as a reagent for the synthesis of other organic compounds. It is also used in the pharmaceutical industry for the production of certain drugs. The presence of bromine in the molecule makes this compound potentially hazardous and requires careful handling and storage.

InChI:InChI=1/C9H14Br2O4/c1-7(12)14-5-9(3-10,4-11)6-15-8(2)13/h3-6H2,1-2H3

Upstream product

• 5419-74-9 pentaerythritol bisacetate 
• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 
• 108-24-7 acetic anhydride 
• 115-77-5 Pentaerythritol 

Relevant articles and documents

Synthesis of 2-bromomethyl-3-hydroxy-2-hydroxymethyl-propyl pyrimidine and theophylline nucleosides under microwave irradiation. Evaluation of their activity against hepatitis B virus

Alkylation of 2-methylthiopyrimidin-4(1H)-one (1a) and its 5(6)-alkyl derivatives 1b - d as well as theophylline (7) with 2,2- bis (bromomethyl)-1,3-diacetoxypropane (2) under microwave irradia-tion gave the corresponding acyclonucleosides 1-[(3-acetoxy-2-acetoxymethyl-2-bromomethyl) prop-1- yl ]-2-methyl-thio pyrmidin-4(1H)-ones 3a - d and 7-[(3-acetoxy-2- acetoxymethyl-2-bromomethyl)prop-1- yl]theophylline (8), which upon further irradiation gave the double-headed acyclonucleosides 1,1 ′-[(2,2- diacetoxymethyl)-1,3-propylidene]- bis [(2-(methylthio)-pyrimidin-4(1H)-ones] 4a - c , and 7,7 ′-[(2,2-diacetoxymethyl)-1,3-propylidene]- bis (theophylline) (9). The deacetylated derivatives were obtained by the action of sodium methoxide. The activity of deacetylated nucleosides against Hepatitis B virus was evaluated. Compound 5b showed moderate inhibition activity against HBV with mild cytotoxicity. Copyright Taylor & Francis Group, LLC.