34966-50-2

Basic information

• Product Name: Methyl 2-(3-chlorophenyl)-2-oxoacetate
• Synonyms: Methyl 2-(3-chlorophenyl)-2-oxoacetate;3-Chloro-oxo-benzeneacetic acid methyl ester;Methyl 3-chlorobenzoylformate
• CAS NO: 34966-50-2
• Molecular Formula: C₉H₇ClO₃
• Molecular Weight: 198.60308
• Mol File: 34966-50-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 44-45 °C
• Boiling Point: 292.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.298±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-(3-chlorophenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(3-chlorophenyl)-2-oxoacetate(34966-50-2)
• EPA Substance Registry System: Methyl 2-(3-chlorophenyl)-2-oxoacetate(34966-50-2)

Safety Data

• Hazardous Substances Data: 34966-50-2(Hazardous Substances Data)

Upstream product

• 264882-01-1 methyl 3-chlorophenyldiazoacetate 
• 67-56-1 methanol 
• 99-02-5 3'-Chloroacetophenone 
• 74-88-4 methyl iodide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 18166-02-4 N-trimethylsilylmethylamine 
• 124-38-9 carbon dioxide 
• 68185-97-7 (3-chlorophenyl)(trimethylsilyl)methanone 
• 553-90-2 Dimethyl oxalate 
• 108-37-2 1-bromo-3-chlorobenzene 
• 53088-68-9 methyl 3-chlorophenylacetate 
• 13305-18-5 (3-chlorophenyl)hydroxyacetic acid methyl ester 

Downstream Products

• 1005478-37-4 methyl (S)-2-(3-chlorophenyl)-2-hydroxypropionate 
• 60300-84-7 methyl α-benzyloxyphenylacetate 
• 26767-07-7 2-(3-chlorophenyl)-2-oxoacetic acid 
• 16273-37-3 (S)-2-(3-chlorophenyl)-2-hydroxyacetic acid 
• 190433-54-6 N-benzyl-2-(3-chlorophenyl)-2-oxoacetamide 
• 34038-83-0 2-(3-Chloro-phenyl)-3-methyl-but-2-enoic acid methyl ester 

Relevant articles and documents

Tris(pentafluorophenyl)borane-Catalyzed Oxygen Insertion Reaction of α-Diazoesters (α-Diazoamides) with Dimethyl Sulfoxide

A tris(pentafluorophenyl)borane-catalyzed oxidation reaction of α-diazoesters (α-diazo amides) with dimethyl sulfoxide has been developed. The reaction proceeds under metal free conditions to afford a series α-ketoesters and α-ketoamides. The synthetic utility of this protocol is demonstrated through synthetic transformations and scaled-up synthesis. (Figure presented.).

Preparation method of alpha-ketoester compound

The invention discloses a preparation method of an alpha-ketone ester compound. The method specifically comprises the following operation steps: adding raw materials alpha-diazo ester and an organic photocatalyst into a reaction flask, then adding an organic solvent, and reacting for 2-12 hours in air at room temperature under the irradiation of a visible light lamp; after the reaction is monitored by thin-layer chromatography (TLC), stopping the reaction, and extracting a reaction solution by using ethyl acetate; concentrating the extracting solution under reduced pressure to obtain a crude product, and performing column chromatography separation on the crude product to obtain the alpha-diazonium ester compound. According to the preparation method, clean visible light is used as reaction energy, cheap organic dye is used as a photocatalyst, air is used as a green oxidizing agent and an oxygen source, and the preparation method has the advantages of simplicity and convenience in operation, no metal residue and mild reaction conditions.

CuO-catalyzed oxidation of aryl acetates with aqueous tert-butyl hydroperoxide for the synthesis of α-ketoesters

A practical method to access α-ketoesters from readily available aryl acetates is developed. In this approach, aqueous tert-butyl hydroperoxide and CuO are employed. No additional solvents are required and it was found that the peroxide side products in the reaction can be decomposed by pyridine.