34988-34-6

Basic information

• Product Name: N-[(3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ylidene)amino]-4-methyl-benzenesulfonamide
• CAS NO: 34988-34-6
• Molecular Formula: C₂₆H₃₆N₂O₃S
• Molecular Weight: 456.649
• Mol File: 34988-34-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 606.4°Cat760mmHg
• Flash Point: 320.5°C
• Density: 1.33g/cm³
• CAS DataBase Reference: N-[(3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ylidene)amino]-4-methyl-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ylidene)amino]-4-methyl-benzenesulfonamide(34988-34-6)
• EPA Substance Registry System: N-[(3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ylidene)amino]-4-methyl-benzenesulfonamide(34988-34-6)

Safety Data

• Hazardous Substances Data: 34988-34-6(Hazardous Substances Data)

Upstream product

• 53-43-0 dehydroepiandrosterone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 154229-19-3 abiraterone 

Relevant articles and documents

Synthesis of the anti-prostate cancer drug abiraterone acetate

Abiraterone acetate is used for the treatment of castration-resistant prostate cancer. Abiraterone acetate was synthesized from dehydroepiandrosterone via a three-step reaction including the formation of tosylhydrazone, cross-coupling reaction and acetylation, and a two-step purification including column chromatography and recrystallization with an overall yield of 51.9%. Here, an improved procedure for the preparation of abiraterone acetate is described. This synthetic process is of easy operation and low cost, which is suitable for industrialization.

SYNTHESIS OF ABIRATERONE AND RELATED COMPOUNDS

The present invention relates to processes for obtaining abiraterone and derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C—C coupling through a steroid hydrazone of general formula (II), as well as to intermediates useful in said processes.

Processes for the preparation of abiraterone and related compouds

The present invention relates to processes for obtaining abiraterone and derivatives thereof, such as abiraterone acetate, by means of a C-C coupling through a steroid hydrazone of general formula (II) or a Suzuki coupling through a steroid borate of general formula (IV), as well as to intermediates useful in said processes.