350-29-8

Basic information

• Product Name: 3-Fluoro-4-hydroxybenzoic acid
• Synonyms: RARECHEM AL BO 0869;3-FLUORO-4-HYDROXYBENZOIC ACID;3-FLUORO-4-HYDROXYBENZOIC ACID HYDRATE;3-fluoro-4-hydroxybenzoate;3-FLUORO-4-HYDROXYBENZOIC ACID 98%;4-Carboxy-2-fluorophenol;3-Fluoro-4-hydroxybe;Benzoic acid, 3-fluoro-4-hydroxy-
• CAS NO: 350-29-8
• Molecular Formula: C₇H₅FO₃
• Molecular Weight: 156.11
• EINECS: 1806241-263-5
• Product Categories: blocks;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Acids & Esters;Fluorine Compounds;Phenols;C7;Carbonyl Compounds;Carboxylic Acids;Fluorine series;Pyridines ,Halogenated Heterocycles
• Mol File: 350-29-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 154-158 °C(lit.)
• Boiling Point: 311.9 °C at 760 mmHg
• Flash Point: 142.4 °C
• Appearance: Off-white to brown/Powder or Crystalline Powder
• Density: 1.492 g/cm³
• Vapor Pressure: 0.000234mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.23±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 2829823
• CAS DataBase Reference: 3-Fluoro-4-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-hydroxybenzoic acid(350-29-8)
• EPA Substance Registry System: 3-Fluoro-4-hydroxybenzoic acid(350-29-8)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• TSCA: N
• HazardClass: IRRITANT
• Hazardous Substances Data: 350-29-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

Uses

3-Fluoro-4-hydroxybenzoic acid may be used in the preparation of (S)-2-methylbutyl-3-fluoro-4-hydroxy benzoate and 4-n-alkoxy-3-fluorobenzoic acids. It may also be used in the synthesis of bis 3-fluoro-4-hydroxybenzoates, which are potent KCa2/3 pan-inhibitors.

General Description

3-Fluoro-4-hydroxybenzoic acid is a halo-substituted 4-hydroxybenzoic acid that can be prepared from 3-fluoro-4-methoxybenzoic acid via demethylation.

InChI:InChI=1/C7H5FO3/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3,9H,(H,10,11)/p-1

Upstream product

• 331-62-4 3-fluoro-4-methoxybenzonitrile 
• 130474-38-3 3,4-isopropylidenequinide 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 85118-04-3 (3,4-difluoro-phenyl)-amide 
• 367-12-4 2-fluorophenol 
• 2105-94-4 4-bromo-2-fluorophenol 
• 257876-94-1 (3aR,7aR)-7,7-Difluoro-2,2-dimethyl-3a,4,7,7a-tetrahydro-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 97205-16-8 methyl 4,5-O-isopropylidene-3-dehydro-4-epi-shikimate 
• 2357-52-0 3-fluoro-4-methoxyphenyl bromide 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 257876-95-2 (4R,5R)-3,3-Difluoro-4,5-dihydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 99-96-7 4-hydroxy-benzoic acid 
• 15719-64-9 methylammonium carbonate 

Downstream Products

• 326-76-1 4-butoxy-3-fluoro-benzoic acid 
• 403-20-3 3-fluoro-p-anisic acid 
• 7247-24-7 4-n-hexyloxy-3-fluorobenzoic acid 
• 403-01-0 methyl 3-fluoro-4-hydroxybenzoate 
• 132248-00-1 3-fluoro-4-undecyloxy-benzoic acid 
• 183664-17-7 4-(4-Butylcarbamoyl-benzyloxy)-3-fluoro-benzoic acid methyl ester 
• 183664-19-9 4-(4-Butylcarbamoyl-benzyloxy)-3-fluoro-benzoic acid 
• 183664-21-3 4-(4-Butylcarbamoyl-benzyloxy)-3-fluoro-benzoic acid pentafluorophenyl ester 
• 636794-21-3 3-fluoro-4-(4-fluoro-benzyloxy)-benzoic acid 4-fluoro-benzyl ester 
• 742067-10-3 3-fluoro-4-hydroxy-N-propyl-benzamide 
• 56355-21-6 ethyl 3-fluoro-4-hydroxybenzoate 
• 930576-23-1 4-(2-carbamoylpyridin-4-yloxy)-3-fluorobenzoic acid 
• 536974-94-4 [4-(benzyloxy)-3-fluorophenyl]methanol 
• 203115-97-3 3-fluoro-4-propoxybenzoic acid 

Relevant articles and documents

Preparation of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate

An efficient synthesis of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate in moderate to excellent yields is described. High regioselectivity was observed in some cases. Georg Thieme Verlag Stuttgart.

Influence of fluoro substituents on the mesophase behaviour of banana-shaped molecules

Three new series of bent-shaped five-ring liquid crystals, based on the ester of isophthalic acid as the central core and azomethine linkages, are presented. They differ by the number and the position of halogeno substituents on the outer rings. This lateral substitution strongly influences the type of mesophases formed. Calculations were performed to determine the modification of the distribution of charge along the different molecules.

Synthesis of 3-deoxy-3,3-difluoroshikimic acid and its 4-epimer from quinic acid

3-Deoxy-3,3-difluoroshikimic acid 2 and its 4-epimer 3 as new analogues of shikimic acid have been synthesised from quinic acid in overall yields of 30% and 12%, respectively.