367-12-4 Usage
Chemical Properties
Clear colourless to yellow liquid
Synthesis Reference(s)
Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015
General Description
Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3.
Air & Water Reactions
Highly flammable.
Reactivity Profile
2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic and irritant.
Purification Methods
Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.]
Check Digit Verification of cas no
The CAS Registry Mumber 367-12-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 367-12:
(5*3)+(4*6)+(3*7)+(2*1)+(1*2)=64
64 % 10 = 4
So 367-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5FO/c7-5-3-1-2-4-6(5)8/h1-4,8H
367-12-4Relevant articles and documents
AROMATIC FLUORINE CHEMISTRY. PART 3. PREPARATION OF FLUOROPHENOLS VIA HYDROLYSIS OF CHLOROFLUOROBENZENES
Pews, R. G.,Gall, J. A.
, p. 377 - 380 (1990)
The 1,2-, 1,3-, and 1,4-fluorophenols have been prepared by a copper (e.g.CuO, CuSO4) catalyzed hydrolysis of chlorofluorobenzenes under conditions of controlled pH.
Decarboxylative Hydroxylation of Benzoic Acids
Ritter, Tobias,Su, Wanqi,Xu, Peng
, p. 24012 - 24017 (2021/10/06)
Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.
Method for preparing O-fluorophenol by one-pot method
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Paragraph 0023-0025, (2021/04/14)
The invention discloses a method for preparing o-fluorophenol by a one-pot method, and belongs to the technical field of organic synthesis. O-bromine/chlorofluorobenzene is used as a raw material, a 2-fluorophenyl Grignard reagent is obtained through magnesium metal or Grignard reagent exchange in the presence of a stabilizer, and then oxygen or compressed air is introduced to obtain the o-fluorophenol. The method is simple and convenient in reaction operation, less in three wastes, high in yield and free of isomers, inhibits elimination of a Grignard reagent due to addition of the stabilizer, and accords with industrial amplification prospects.