351-98-4

Basic information

• Product Name: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-
• CAS NO: 351-98-4
• Molecular Formula: C14H10F3N
• Molecular Weight: 249.235
• Mol File: 351-98-4.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(351-98-4)
• EPA Substance Registry System: Benzenamine, N-(phenylmethylene)-4-(trifluoromethyl)-(351-98-4)

Safety Data

• Hazardous Substances Data: 351-98-4(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 100-52-7 benzaldehyde 
• 26456-05-3 10-methylacridinium perchlorate 
• 5586-13-0 1-azido-4-(trifluoromethyl)benzene 
• 100-51-6 benzyl alcohol 
• 402-54-0 p-nitrobenzotrifluoride 
• 23056-94-2 2-methyl-1-hexen-3-yne 
• 538-51-2 benzylidene phenylamine 

Downstream Products

• 143874-20-8 (3R,4S)-3,4-Diphenyl-1-(4-trifluoromethyl-phenyl)-azetidin-2-one 
• 1309576-55-3 (1E,2Z)-3-{1-[(p-trifluoromethylphenyl)imino]-2-(trimethylsilyl)-3-phenyl-2-propenyl}-4,4-dimethyl-1,3-oxazolidine-2-one 
• 1309576-54-2 (1E,2E)-3-{1-[(p-trifluoromethylphenyl)imino]-2-(trimethylsilyl)-3-phenyl-2-propenyl}-4,4-dimethyl-1,3-oxazolidine-2-one 
• 1621980-91-3 C₃₀H₃₈F₃N 
• 1621981-02-9 C₂₈H₃₀F₃N 
• 33768-43-3 N-(2-formylphenyl)benzamide 
• 1310569-12-0 2,2,2-trifluoro-N-(4-(trifluoromethyl)phenyl)ethanethioamide 
• 405-81-2 N-benzyl-4-(trifluoromethyl)aniline 

Relevant articles and documents

Rhodium(III)-amine dual catalysis for the oxidative coupling of aldehydes by directed C-H activation: Synthesis of phthalides

A novel oxidative coupling of aldehydes to form C3-substituted phthalides facilitated by co-operative dual catalysis of a Rh(III) complex and an aryl amine is reported. The reaction involves a cascade ortho C-H activation-insertion-annulation sequence. This methodology is efficient and applicable for the homo- and heterocoupling of various functionalized aldehydes generating the corresponding phthalides in moderate to high yields.

Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction

The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, for this multistep procedure, the sacrificial phosphine has to be used, resulting in difficulties in the purification process and waste disposal at the same time. Here, we report a redox-neutral azide-alcohol imination methodology enabled by a base-metal nickel PN3 pincer catalyst. The one-step, waste-free, and high atom-economical features highlight its advantages further. Moreover, mechanistic insight suggests a non-metal-ligand cooperation pathway based on the observation of an intermediate and density functional theory calculations.

Ru(II)-NHC catalysed N-Alkylation of amines with alcohols under solvent-free conditions

The reaction of [RuCl2(p-cymene)]2 with in situ prepared Ag-N-heterocyclic carbene (NHC) complexes yields a series of [RuCl2(p-cymene)(NHC)] complexes (2). All of the complexes have been characterised by elemental analysis, and 1H NMR and 13C NMR spectroscopies. These complexes have been tested for the N-alkylation of aromatic amines with arylmethyl alcohols under neat conditions in the presence of KOtBu at 120 °C. Compounds (2) are stable and have high catalytic/selective activity for the N-alkylation reactions of primary amines to afford secondary amines.