351019-18-6 Usage
Description
2-Fluoropyridine-5-boronic acid is an organic compound with the chemical formula C5H5BFNO2. It is a white to light yellow solid and is commonly used in various chemical reactions and synthesis processes due to its unique chemical properties.
Uses
Used in Suzuki Reaction:
2-Fluoropyridine-5-boronic acid is used as a reagent in the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds, particularly in the synthesis of biaryl compounds. Its boronic acid functionality allows for the formation of stable organometallic intermediates, facilitating the coupling process and enhancing the overall efficiency of the reaction.
Used in Synthesis of Halohydroxypyridines:
2-Fluoropyridine-5-boronic acid is used as a starting material in the synthesis of halohydroxypyridines through hydroxydeboronation with basic hydrogen peroxide. This process involves the conversion of the boronic acid group to a hydroxyl group, resulting in the formation of halohydroxypyridine derivatives, which are valuable intermediates in the development of various pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
2-Fluoropyridine-5-boronic acid is used as a building block for the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of neurological disorders, inflammation, and cancer. Its unique structure and reactivity make it a versatile component in the design and development of novel therapeutic agents.
Used in Chemical Research:
2-Fluoropyridine-5-boronic acid is used as a research tool in the field of organic chemistry, where it is employed to study the reactivity and selectivity of various chemical reactions. Its boronic acid functionality allows for the exploration of new synthetic pathways and the development of innovative strategies for the construction of complex molecular architectures.
Check Digit Verification of cas no
The CAS Registry Mumber 351019-18-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,0,1 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 351019-18:
(8*3)+(7*5)+(6*1)+(5*0)+(4*1)+(3*9)+(2*1)+(1*8)=106
106 % 10 = 6
So 351019-18-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BFNO2/c7-5-3-1-2-4(8-5)6(9)10/h1-3,9-10H
351019-18-6Relevant articles and documents
PHARMACEUTICAL COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
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Page/Page column 54-55; 57-58, (2009/05/28)
The invention relates to a pharmaceutical composition comprising 2-(5-(4-(2- mopholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
Pyrazolo[1,5-a]pyridine antiherpetics: Effects of the C3 substituent on antiviral activity
Johns, Brian A.,Gudmundsson, Kristjan S.,Allen, Scott H.
, p. 2858 - 2862 (2008/02/04)
A recently disclosed series of pyrazolo[1,5-a]pyridine inhibitors of herpes virus replication has been closely examined herein for effects of the C3 substituent on antiviral activity. Significant changes in activity are observed by alterations of the hete
SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER
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Page/Page column 93, (2010/02/12)
Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.