35572-79-3

Basic information

• Product Name: 4-IODO-2,6-DINITROTOLUENE
• Synonyms: 4-IODO-2,6-DINITROTOLUENE;4-Chloro-2,6-dinitrotoluene;2,6-dinitro-4-chloro toluene;2,6-dinitro-4-chloro-tolurene;5-chloro-2-methyl-1,3-dinitrobenzene
• CAS NO: 35572-79-3
• Molecular Formula: C₇H₅ClN₂O₄
• Molecular Weight: 308.03
• EINECS: 200-258-5
• Mol File: 35572-79-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 74-75 °C
• Boiling Point: 291.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.532±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-IODO-2,6-DINITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-2,6-DINITROTOLUENE(35572-79-3)
• EPA Substance Registry System: 4-IODO-2,6-DINITROTOLUENE(35572-79-3)

Safety Data

• Hazardous Substances Data: 35572-79-3(Hazardous Substances Data)

Usage

General Description

4-Iodo-2,6-Dinitrotoluene is a chemical compound known for its use in organic synthesis due to its stability and reactivity. Its chemical formula is C7H5IN2O4 and it has a molecular weight of 340 g/mol. The compound features an aromatic benzene ring, which is attached to three functional groups: an iodo group, a methyl group and two nitro groups. This uniquely positions it for use in various chemical reactions. Its key properties include strong oxidizing abilities and electrophilic aromatic substitution, making it useful in the synthesis of other complex molecules. It is often used in the fields of pharmaceuticals, explosives, dyes, and polymers. However, as with many chemicals, it must be handled with care due to its potential for harmful effects on human health and the environment.

Upstream product

• 89-59-8 4-chloro-2-nitrotoluene 
• 7697-37-2 nitric acid 
• 606-20-2 2,6-dinitrotoluene 
• 540-80-7 tert.-butylnitrite 
• 75-09-2 dichloromethane 
• 19406-51-0 4-Amino-2,6-dinitrotoluene 
• 7447-39-4 copper(II) chloride 
• 118-96-7 2,4,6-Trinitrotoluene 
• 603-12-3 2,6-dinitrobenzoic acid 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 219312-44-4 5-chloro-2-methyl-3-nitro-aniline 
• 885519-32-4 6-chloro-1H-indazol-4-amine 
• 64346-04-9 2-nitro-4,6-dichloro-toluene 
• 95192-57-7 4-chloro-2,6-dinitrobenzoic acid 
• 1254036-71-9 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole 
• 1364802-72-1 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-86-6 6-chloro-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole 
• 1254036-84-4 4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole 
• 1254036-83-3 {2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol 
• 1254036-82-2 methyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1254036-81-1 ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate 
• 1254036-94-6 6-chloro-4-iodo-1-(phenylsulfonyl)-1H-indazole 
• 885519-56-2 6-chloro-4-iodo-1H-indazole 
• 870606-29-4 5-chloro-3-iodo-2-methylaniline 

Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.

Indazole compounds and application thereof to preparation of IDO inhibitors

The invention discloses indazole compounds as shown in a formula (i) or (II) which is described in the specification, and a preparation method thereof, and application of the compounds as IDO inhibitors. The compounds provided by the invention can be used for preventing and/or treating a plurality of diseases, such as Alzheimer's disease, cataract, infections related to cellular immune activation,autoimmune diseases, AIDS, cancers, depression, the metabolic disorder of tryptophan or the like.

Polysubstituted-indazole compounds and application of same as IDO inhibitors

The invention discloses polysubstituted-indazole compounds as shown in a formula (I) which is described in the specification, a preparation method for the compounds, and application of the compounds as IDO inhibitors. The compounds provided by the invention can be used for preventing and/or treating a plurality of diseases, such as Alzheimer's disease, cataract, infections related to cellular immune activation, autoimmune diseases, AIDS, cancers, depression, the metabolic disorder of tryptophan or the like.