356534-04-8

Basic information

• Product Name: (4-fluoro-2-methylphenyl)hydrazine
• Synonyms: (4-Fluoro-2-methylphenyl)hydrazine;(4-fluoro-2-Methylphenyl)hydrazine hydrochloride
• CAS NO: 356534-04-8
• Molecular Formula: C₇H₉FN₂
• Molecular Weight: 140.16
• Mol File: 356534-04-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 215.4°C at 760 mmHg
• Flash Point: 84.1°C
• Appearance: /
• Density: 1.202
• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.594
• PKA: 5.36±0.27(Predicted)
• CAS DataBase Reference: (4-fluoro-2-methylphenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluoro-2-methylphenyl)hydrazine(356534-04-8)
• EPA Substance Registry System: (4-fluoro-2-methylphenyl)hydrazine(356534-04-8)

Safety Data

• Hazardous Substances Data: 356534-04-8(Hazardous Substances Data)

Usage

General Description

"(4-Fluoro-2-methylphenyl)hydrazine" is a chemical compound that is part of the hydrazine family, characterized by the presence of a fluoro and a methyl group on a phenyl ring. Hydrazine compounds are generally known for their high reactivity and wide range of uses in chemical synthesis. It is important to note that hydrazines are often highly toxic and should be handled with care to avoid exposure, especially in its pure form. This particular compound, with its additional fluoro and methyl groups, can exhibit unique reactivity patterns and may be applied in specific synthesis processes. However, detailed information about its exact usage and properties is limited.

InChI:InChI=1/C7H9FN2/c1-5-4-6(8)2-3-7(5)10-9/h2-4,10H,9H2,1H3

Upstream product

• 452-63-1 2-Bromo-5-fluorotoluene 
• 452-71-1 4-fluor-2-methylaniline 

Relevant articles and documents

Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine

Reported here is the Pd-catalyzed C–N coupling of hydrazine with (hetero)aryl chlorides and bromides to form aryl hydrazines with catalyst loadings as low as 100 ppm of Pd and KOH as base. Mechanistic studies revealed two catalyst resting states: an arylpalladium(II) hydroxide and arylpalladium(II) chloride. These compounds are present in two interconnected catalytic cycles and react with hydrazine and base or hydrazine alone to give the product. The selectivity of the hydroxide complex with hydrazine to form aryl over diaryl hydrazine was lower than that of the chloride complex, as well as the catalytic reaction. In contrast, the selectivity of the chloride complex closely matched that of the catalytic reaction, indicating that the aryl hydrazine is derived from this complex. Kinetic studies showed that the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpalladium(II) chloride complex to give an arylpalladium(II) hydrazido complex.

FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.