365441-83-4

Basic information

• Product Name: Carbamic acid, [(4-methylphenyl)[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 365441-83-4
• Molecular Formula: C20H25NO4S
• Molecular Weight: 375.489
• Mol File: 365441-83-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(4-methylphenyl)[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(4-methylphenyl)[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester(365441-83-4)
• EPA Substance Registry System: Carbamic acid, [(4-methylphenyl)[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester(365441-83-4)

Safety Data

• Hazardous Substances Data: 365441-83-4(Hazardous Substances Data)

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 104-87-0 4-methyl-benzaldehyde 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 1207386-20-6 ((1S,2S)-2-methyl-3-oxo-1-(p-tolyl)propyl)carbamic acid tert-butyl ester 
• 80907-22-8 ethyl 2?(4?oxo?2?p?tolyl?4H?chromen?3?yl)acetate 
• 1234882-85-9 tert-butyl (1S,2R)-2-formyl-3-methyl-1-p-tolylbutylcarbamate 
• 1234882-97-3 C₁₈H₂₇NO₃ 
• 1030825-50-3 C₁₆H₂₄N₂O₄ 
• 479423-39-7 4-methylbenzaldehyde N-(tert-butoxycarbonyl)imine 

Relevant articles and documents

Leaving group and regioselectivity switches in the aminoalkylation reaction of indoles and related heterocycles with α-amido sulfones

The regioselective aminoalkylation of indoles and related heterocycles with α-amido sulfones under basic conditions has been studied. The reaction that employed the MeMgBr/MgBr2 system provided high yields of 3-(1-carbamoylalkyl)indoles. On the other hand, the reaction that used Cs 2CO3 afforded 1-(1-carbamoylalkyl)indoles exclusively in high yields. The first reaction constitutes a switch of the leaving group of the α-amido sulfone in comparison to previously reported reactions between indoles and α-amido sulfones, which provided 3-(1-arylsulfonylalkyl) indoles. The second reaction constitutes a switch in the regioselectivity. The extensions of these C- and N-aminoalkylations starting from pyrroles and 7-azaindole have also been studied. Structurally diverse aminoalkylated indoles, pyrroles, and 7-azaindoles were obtained with excellent yield in most of the cases. The regioselective aminoalkylation of indoles and heterocycles with α-amido sulfones under basic conditions is described. The reaction with MeMgBr/MgBr2 gives 3-(1-carbamoylalkyl)indoles, whereas employing Cs2CO3 yields 1-(1-carbamoylalkyl)indoles. The first case presents a switch of the leaving group of the α-amido sulfone, whereas the second demonstrates a switch in the regioselectivity. Copyright

Reductive BOC-amination of aldehydes

Base-assisted elimination-reduction of α-amidoalkyl sulfones with sodium borohydride proceeds in tetrahydrofuran at room temperature leading to the corresponding BOC-amines in good yields.