374-01-6

Basic information

• Product Name: 1,1,1-TRIFLUORO-2-PROPANOL
• Synonyms: 1,1,1-trifluoro-2-propano;1-Methyl-2,2,2-trifluoroethanol;2-Propanol, 1,1,1-trifluoro-;2-propanol,1,1,1-trifluoro-;1,1,1-TRIFLUORO-2-PROPANOL;1,1,1-TRIFLUOROPROPAN-2-OL;1,1,1-TRIFLUOROPROPANOL-2;1,1,1-TRIFLUOROISOPROPANOL
• CAS NO: 374-01-6
• Molecular Formula: C₃H₅F₃O
• Molecular Weight: 114.07
• EINECS: 206-773-2
• Product Categories: Alcohols;C2 to C6;Oxygen Compounds
• Mol File: 374-01-6.mol
• Article Data: 35

Chemical Properties

• Melting Point: -52 °C
• Boiling Point: 81-82 °C(lit.)
• Flash Point: 65 °F
• Appearance: /
• Density: 1.259 g/mL at 25 °C(lit.)
• Vapor Pressure: 109mmHg at 25°C
• Refractive Index: n20/D 1.316(lit.)
• PKA: 12.53±0.20(Predicted)
• Water Solubility: Fully miscible in water.
• BRN: 1734738
• CAS DataBase Reference: 1,1,1-TRIFLUORO-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUORO-2-PROPANOL(374-01-6)
• EPA Substance Registry System: 1,1,1-TRIFLUORO-2-PROPANOL(374-01-6)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-33-36
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 3
• TSCA: T
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 374-01-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Uses

1,1,1-Trifluoro-2-propanol is used as a chemical building block.

General Description

1,1,1-Trifluoro-2-propanol, a fluoroalcohol, is an organic solvent. Vibrational spectral analysis of OH and OD groups of 1,1,1-trifluoro-2-propanol and its deuterated derivatives has been conducted.

InChI:InChI=1/C3H5F3O/c1-2(7)3(4,5)6/h2,7H,1H3/t2-/m0/s1

Upstream product

• 359-41-1 1,1,1-trifluoro-2,3-epoxypropane 
• 917-64-6 methyl magnesium iodide 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 677-21-4 1,1,1-trifluoropropylene 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 274-07-7 benzo[1,3,2]dioxaborole 
• 130025-34-2 (S)-2-trifluoromethyl-oxirane 
• 67-56-1 methanol 
• 18454-30-3 (+)-3-(1-trifluoromethylethoxy)propionic acid 
• 143142-90-9 (2R)-2-(trifluoromethyl)oxirane 
• 887144-97-0 Togni's reagent 
• 767-99-7 2-phenylbut-2-ene 

Downstream Products

• 400-37-3 acetic acid-(β,β,β-trifluoro-isopropyl ester) 
• 99366-91-3 2-chloro-4-nitro-1-((1,1,1-trifluoropropan-2-yl)oxy)benzene 
• 1156542-42-5 4-(2,2,2-trifluoro-1-methylethoxy)pyridine-2-carbonitrile 
• 1196485-88-7 4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid 2,2,2-trifluoro-1-methyl-ethyl ester 
• 845616-83-3 rac-5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid 
• 87014-38-8 p-(1,1,1-Trifluoroisopropoxy)benzonitrile 
• 1246442-51-2 carbonic acid 4-nitro-phenyl ester (S)-2,2,2-trifluoro-1-methyl-ethyl ester 
• 1255649-22-9 (rac)-1-nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene 
• 1192258-84-6 N-tert-butyl-2-(2,2,2-trifluoro-1-methylethoxy)benzenesulfonamide 
• 1355063-57-8 4-{[5-Chloro-6-(2,2,2-trifluoro-1-methylethoxy)pyridin-3-yl]oxy}-2,5-difluoro-N-(methylsulfonyl)benzamide 
• 1415818-17-5 (R)-1,1,1-trifluoropropan-2-yl 4-((1r,4r)-4-(3-iodopyridin-4-yloxy)cyclohexyloxy)piperidine-1-carboxylate 
• 1415818-05-1 (R)-1,1,1-trifluoropropan-2-yl 4-((1r,4r)-4-(3-cyanopyridin-4-yloxy)cyclohexyloxy)piperidine-1-carboxylate 

Relevant articles and documents

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ION CHANNEL MODULATORS

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Method for oxidative cracking of compound containing unsaturated double bonds

The invention relates to a method for oxidative cracking of a compound containing unsaturated double bonds. The method comprises the following steps: (A) providing a compound (I) containing unsaturated double bonds, a trifluoromethyl-containing reagent and a catalyst, wherein the catalyst is shown as a formula (II): M(O)mL1yL2z (II), M, L1, L2, m, y, z, R1, R2 and R3 being defined in the specification; and (B) mixing the compound containing the unsaturated double bonds and the trifluoromethyl-containing reagent, and performing an oxidative cracking reaction on the compound containing the unsaturated double bonds in the presence of air or oxygen by using the catalyst to obtain a compound represented by formula (III),.

ION CHANNEL MODULATORS

Provided, in part, are compounds of Formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.