37641-48-8Relevant articles and documents
Synthesis and structure analysis of 2-(2′-propanonylthio)-3-(o-methyl phenyl) quinazol-4(3H)-one
Rajnikant,Dinesh,Mousmi,Deshmukh,Patil,Sawhney, Anshu
, p. 693 - 696 (2004)
The three-dimensional molecular and crystal structure of 2-(2′-propanonylthio)3-(o-methyl phenyl)quinazol-4(3H)-one has been determined by X-ray crystallographic methods. This compound crystallizes in the orthorhombic space group Pbca with unit
Enhancement of Different Biomedical Activities of Newly Synthesized Quinazoline Derivatives
Zeid, Ibrahim F.,Kassem, Emad M.,Mohamed, Neama A.,Salman, Ahmed A.,Shalaby, Al Shimaa G.
, p. 1280 - 1290 (2018/06/20)
A series of newly synthesized compounds of quinazolinone by various substituents was screened for its pharmacological activities. These included their action as antibacterial agents against pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa) and as antifungal agents against Aspergillus niger and pathogenic yeast (Candida albicans). The presently investigated compounds were synthesized in higher yields, and the structure features were elucidated on the basis of IR, 1H-NMR, and mass and elemental analysis data. These compounds were also evaluated as antioxidant agent. The results revealed that six compounds (2a, 11b, 11a, 2b, 13a, and 3c) exhibited higher antimicrobial activity against the tested pathogenic strains. In addition, it was found that compound 6a exhibited a radical scavenging activity higher than other studied compounds.
Nanomagnetically modified polyphosphoric acid (NiFe2O4@SiO2-PPA): An efficient, fast, and reusable catalyst for the synthesis of 2-thioxoquinazolinones under solvent-free conditions
Eshghi, Hossein,Khojastehnezhad, Amir,Moeinpour, Farid,Bakavoli, Mehdi,Zeinabi, Nafiseh,Allameh, Sadegh
, p. 7915 - 7924 (2015/04/16)
Polyphosphoric acid functionalized silica-coated magnetic nanoparticles with core-shell structure (NiFe2O4@SiO2-PPA) has been used as a magnetically recyclable green catalyst for the one-pot three-component synthesis of 2-thioxoquinazolinones by the reaction of isatoic anhydride, primary amines and thiourea under neat conditions. The catalyst is readily recovered by simple magnetic decantation and can be recycled five times with no significant loss of catalytic activity.
