376591-94-5

Basic information

• Product Name: 2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid
• Synonyms: 2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid;2'-Methoxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid;3-(2-methoxy-3-nitrophenyl)benzoic acid;Eltrombopag olamine Intermediate 3
• CAS NO: 376591-94-5
• Molecular Formula: C₁₄H₁₁NO₅
• Molecular Weight: 273.24084
• Mol File: 376591-94-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 467.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.345±0.06 g/cm3(Predicted)
• PKA: 3.95±0.10(Predicted)
• CAS DataBase Reference: 2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid(376591-94-5)
• EPA Substance Registry System: 2'-Methoxy-3'-nitro-biphenyl-3-carboxylic acid(376591-94-5)

Safety Data

• Hazardous Substances Data: 376591-94-5(Hazardous Substances Data)

Usage

Uses

2''-Methoxy-3''-nitro-[1,1''-biphenyl]-3-carboxylic Acid is a reagent which can be used for preparation of pyrazolone derivatives useful in thrombocytopenia treatment

Upstream product

• 25487-66-5 3-Carboxyphenylboronic acid 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 95-56-7 2-hydroxybromobenzene 
• 98775-19-0 2-bromo-6-nitrophenyl methyl ether 

Downstream Products

• 1257792-64-5 3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide 
• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 
• 1176777-42-6 (Z)-2'-hydroxy-3'-[N'-(1-indan-5-yl-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazino]biphenyl-3-carboxylic acid 
• 376591-95-6 2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid 

Relevant articles and documents

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES PHARMACEUTCIAL SALTS, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present invention relates to bicyclo-substituted pyrazolon azo derivatives pharmaceutical acceptable salts of formula (I), methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definition of substituents in formula (I) are the same as the description.

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.

Thrombopoietin mimetics

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.