376591-95-6

Basic information

• Product Name: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID
• Synonyms: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID;2'-hydroxy-3'-nitro-3-biphenylcarboxylic acid;2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid;3-(2-hydroxy-3-nitrophenyl)benzoic acid;Eltrombopag olamine Intermediate 2;Eltrombopag o
• CAS NO: 376591-95-6
• Molecular Formula: C₁₃H₉NO₅
• Molecular Weight: 259.216
• Mol File: 376591-95-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 452.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.460±0.06 g/cm3(Predicted)
• Storage Temp.: Room Temperature
• Solubility: Tetrahydrofuran; Methanol
• PKA: 3.96±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID(376591-95-6)
• EPA Substance Registry System: 2-HYDROXY-3''-NITRO-BIPHENYL-3-CARBOXYLIC ACID(376591-95-6)

Safety Data

• Hazardous Substances Data: 376591-95-6(Hazardous Substances Data)

Usage

Uses

3’-Nitro-2’-hydroxy[1,1’]-biphenyl-3-carboxylic Acid is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

Upstream product

• 13073-25-1 2-bromo-6-nitro-phenol 
• 25487-66-5 3-Carboxyphenylboronic acid 
• 95-56-7 2-hydroxybromobenzene 
• 88-75-5 2-hydroxynitrobenzene 
• 618-51-9 3-Iodobenzoic acid 
• 893736-72-6 2′-hydroxy[1,1-biphenyl]-3-carboxylic acid 
• 376591-94-5 2'-methoxy-3'-nitrobiphenyl-3-carboxylic acid 

Downstream Products

• 376591-97-8 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride 
• 376592-93-7 3′-amino-2′-hydroxy biphenyl-3-carboxylic acid 

Relevant articles and documents

Preparation method of eltrombopag

The invention relates to the technical field of medicine manufacturing, and discloses a preparation method of eltrombopag. The preparation method comprises the following steps: 1, sequentially carrying out a continuous reaction on a starting material I, glacial acetic acid and hydrobromic acid until the reaction is completed to obtain an intermediate I; 2, reducing the intermediate I by hydrazinehydrate under catalytic action of palladium to obtain an intermediate II; and 3, carrying out diazotization addition on the intermediate II to obtain the eltrombopag. According to the method, nitryl is prevented from being directly reduced by hydrogen on the premise that the medicine quality is guaranteed, so that production can be safely amplified, and market competitiveness of the variety is improved.

Preparation method of 3'-nitro-2'-hydroxybiphenyl-3-formic acid

The invention provides a preparation method of 3'-nitro-2'-hydroxybiphenyl-3-formic acid. The method uses 2-halogenated acrolein and nitromethane as starting raw materials, obtains 2-halo-4-nitro-n-butyraldehyde through an addition reaction, obtains 2-(3-

THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS

Disclosed herein are substituted arylhydrazino compounds, pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.